Pentraxin 3: an Immuno-regulator in the Lungs

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Jun 12

PMID 23755050

Citations 17

Authors

Jyoti Balhara

Latifa Koussih

Jingbo Zhang

Abdelilah Soussi Gounni

Affiliations

Soon will be listed here.

Abstract

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that is a humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to Toll like receptor (TLR) engagement, inflammatory stimuli, and physical and chemical stress. Further, PTX3 plays an essential role in female fertility as it facilitates the organization of extracellular matrix in the cumulus oophorus. Such activity is also implicated in post-inflammation tissue repair. PTX3 is a multifunctional protein and plays a non-redundant role in providing immunity against potential immunological dangers. Thus, we assessed its role in lung immunity, as lungs are at a constant risk of infections and tissue damage that is attributable to perpetual exposure to foreign agents.

Citing Articles

RNA mA methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.

Han X, Liu L, Huang S, Xiao W, Gao Y, Zhou W Nat Commun. 2023; 14(1):7328.

PMID: 37957139 PMC: 10643624. DOI: 10.1038/s41467-023-43219-w.

New Insights on the Role of pentraxin-3 in Allergic Asthma.

Koussih L, Atoui S, Tliba O, Gounni A Front Allergy. 2022; 2:678023.

PMID: 35387000 PMC: 8974764. DOI: 10.3389/falgy.2021.678023.

Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on .

Palmieri F, Koutsokera A, Bernasconi E, Junier P, von Garnier C, Ubags N Front Med (Lausanne). 2022; 9:832510.

PMID: 35386908 PMC: 8977413. DOI: 10.3389/fmed.2022.832510.

Modulation of hyaluronan signaling as a therapeutic target in human disease.

Garantziotis S Pharmacol Ther. 2021; 232:107993.

PMID: 34587477 PMC: 8930430. DOI: 10.1016/j.pharmthera.2021.107993.

PTX3 Deficiency Promotes Enhanced Accumulation and Function of CD11cCD11b DCs in a Murine Model of Allergic Inflammation.

Balhara J, Koussih L, Mohammed A, Shan L, Lamkhioued B, Gounni A Front Immunol. 2021; 12:641311.

PMID: 34305885 PMC: 8299994. DOI: 10.3389/fimmu.2021.641311.

References

Pauwels N, Bracke K, Maes T, van Pottelberge G, Garlanda C, Mantovani A . Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner. Respir Res. 2010; 11:134. PMC: 2959025. DOI: 10.1186/1465-9921-11-134. View

Gout E, Moriscot C, Doni A, Dumestre-Perard C, Lacroix M, Perard J . M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J Immunol. 2011; 186(10):5815-22. DOI: 10.4049/jimmunol.1100180. View

Kao S, Yang H, Tsao S, Cheng C, Bien M, Yu M . Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with community-acquired pneumonia. Clin Chem Lab Med. 2012; 51(4):907-13. DOI: 10.1515/cclm-2012-0459. View

Abderrahim-Ferkoune A, Bezy O, Chiellini C, Maffei M, Grimaldi P, Bonino F . Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells. J Lipid Res. 2003; 44(5):994-1000. DOI: 10.1194/jlr.M200382-JLR200. View

KILBOURNE E, Laver W, SCHULMAN J, Webster R . Antiviral activity of antiserum specific for an influenza virus neuraminidase. J Virol. 1968; 2(4):281-8. PMC: 375612. DOI: 10.1128/JVI.2.4.281-288.1968. View

Aranday Cortes E, Kaveh D, Nunez-Garcia J, Hogarth P, Vordermeier H . Mycobacterium bovis-BCG vaccination induces specific pulmonary transcriptome biosignatures in mice. PLoS One. 2010; 5(6):e11319. PMC: 2893133. DOI: 10.1371/journal.pone.0011319. View

Martin B, Hirota K, Cua D, Stockinger B, Veldhoen M . Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity. 2009; 31(2):321-30. DOI: 10.1016/j.immuni.2009.06.020. View

Gustin C, Delaive E, Dieu M, Calay D, Raes M . Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure. Arterioscler Thromb Vasc Biol. 2007; 28(3):491-7. DOI: 10.1161/ATVBAHA.107.158642. View

Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B . The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol. 2011; 186(9):5425-34. DOI: 10.4049/jimmunol.1002035. View

10.

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R . Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002; 420(6912):182-6. DOI: 10.1038/nature01195. View

11.

Gaziano R, Bozza S, Bellocchio S, Perruccio K, Montagnoli C, Pitzurra L . Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother. 2004; 48(11):4414-21. PMC: 525434. DOI: 10.1128/AAC.48.11.4414-4421.2004. View

12.

Diamandis E, Goodglick L, Planque C, Thornquist M . Pentraxin-3 is a novel biomarker of lung carcinoma. Clin Cancer Res. 2011; 17(8):2395-9. DOI: 10.1158/1078-0432.CCR-10-3024. View

13.

Forbes B . Acquisition of cytomegalovirus infection: an update. Clin Microbiol Rev. 1989; 2(2):204-16. PMC: 358111. DOI: 10.1128/CMR.2.2.204. View

14.

Introna M, Alles V, Castellano M, Picardi G, De Gioia L, Bottazzai B . Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood. 1996; 87(5):1862-72. View

15.

Camozzi M, Zacchigna S, Rusnati M, Coltrini D, Ramirez-Correa G, Bottazzi B . Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo. Arterioscler Thromb Vasc Biol. 2005; 25(9):1837-42. DOI: 10.1161/01.ATV.0000177807.54959.7d. View

16.

Van Pottelberge G, Bracke K, Pauwels N, Vermassen F, Joos G, Brusselle G . COPD is associated with reduced pulmonary interstitial expression of pentraxin-3. Eur Respir J. 2011; 39(4):830-8. DOI: 10.1183/09031936.00138110. View

17.

Endo Y, Matsushita M, Fujita T . The role of ficolins in the lectin pathway of innate immunity. Int J Biochem Cell Biol. 2011; 43(5):705-12. DOI: 10.1016/j.biocel.2011.02.003. View

18.

Lu J, Marnell L, Marjon K, Mold C, Du Clos T, Sun P . Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature. 2008; 456(7224):989-92. PMC: 2688732. DOI: 10.1038/nature07468. View

19.

Rusnati M, Camozzi M, Moroni E, Bottazzi B, Peri G, Indraccolo S . Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis. Blood. 2004; 104(1):92-9. DOI: 10.1182/blood-2003-10-3433. View

20.

Soares A, Souza D, Pinho V, Vieira A, Nicoli J, Cunha F . Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice. Microbes Infect. 2006; 8(5):1321-9. DOI: 10.1016/j.micinf.2005.12.017. View