A Process Analysis of the CA3 Subregion of the Hippocampus

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2013 Jun 11

PMID 23750126

Citations 39

Authors

Raymond P Kesner

Affiliations

Soon will be listed here.

Abstract

From a behavioral perspective, the CA3a,b subregion of the hippocampus plays an important role in the encoding of new spatial information within short-term memory with a duration of seconds and minutes. This can easily be observed in tasks that require rapid encoding, novelty detection, one-trial short-term or working memory, and one-trial cued recall primarily for spatial information. These are tasks that have been assumed to reflect the operations of episodic memory and require interactions between CA3a,b and the dentate gyrus (DG) via mossy fiber inputs into the CA3a,b. The CA3a,b is also important for encoding of spatial information requiring the acquisition of arbitrary and relational associations. All these tasks are assumed to operate within an autoassociative network function of the CA3 region. The CA3a,b also supports retrieval of short-term memory information based on a spatial pattern completion process. Based on afferent inputs into CA3a,b from the DG via mossy fibers and afferents from the entorhinal cortex into CA3a,b as well as reciprocal connections with the septum, CA3a,b can bias the process of encoding utilizing the operation of spatial pattern separation and the process of retrieval utilizing the operation of pattern completion. The CA3a,b also supports sequential processing of information in cooperation with CA1 based on the Schaffer collateral output from CA3a,b to CA1. The CA3c function is in part based on modulation of the DG in supporting pattern separation processes.

Citing Articles

Neural Mechanisms of Learning and Consolidation of Morphologically Derived Words in a Novel Language: Evidence From Hebrew Speakers.

Nathaniel U, Eidelsztein S, Geskin K, Yamasaki B, Nir B, Dronjic V Neurobiol Lang (Camb). 2024; 5(4):864-900.

PMID: 39301207 PMC: 11410356. DOI: 10.1162/nol_a_00150.

Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.

Hanycz S, Noorani A, Hung P, Walker M, Zhang A, Latypov T Pain Rep. 2024; 9(3):e1159.

PMID: 38655236 PMC: 11037743. DOI: 10.1097/PR9.0000000000001159.

BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology.

Griego E, Galvan E Cell Mol Neurobiol. 2023; 43(8):4007-4022.

PMID: 37874456 PMC: 11407739. DOI: 10.1007/s10571-023-01425-6.

The impact of stimulus configuration on visual short-term memory decline in normal aging and mild cognitive impairment.

Sapkota R, van der Linde I, Grunwald I, Upadhyaya T, Lamichhane N, Pardhan S Brain Behav. 2023; 13(9):e3113.

PMID: 37287417 PMC: 10498075. DOI: 10.1002/brb3.3113.

Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.

Nomoto M, Ohkawa N, Inokuchi K, Oishi N Mol Brain. 2023; 16(1):12.

PMID: 36670484 PMC: 9854113. DOI: 10.1186/s13041-023-01004-2.

References

Howard M, Natu V . Place from time: Reconstructing position from a distributed representation of temporal context. Neural Netw. 2005; 18(9):1150-62. PMC: 1444898. DOI: 10.1016/j.neunet.2005.08.002. View

Hargreaves E, Rao G, Lee I, Knierim J . Major dissociation between medial and lateral entorhinal input to dorsal hippocampus. Science. 2005; 308(5729):1792-4. DOI: 10.1126/science.1110449. View

Deco G, Rolls E . Attention, short-term memory, and action selection: a unifying theory. Prog Neurobiol. 2005; 76(4):236-56. DOI: 10.1016/j.pneurobio.2005.08.004. View

OReilly R, Rudy J . Conjunctive representations in learning and memory: principles of cortical and hippocampal function. Psychol Rev. 2001; 108(2):311-45. DOI: 10.1037/0033-295x.108.2.311. View

Levy W . A sequence predicting CA3 is a flexible associator that learns and uses context to solve hippocampal-like tasks. Hippocampus. 1996; 6(6):579-90. DOI: 10.1002/(SICI)1098-1063(1996)6:6<579::AID-HIPO3>3.0.CO;2-C. View

Do V, Martinez C, Martinez Jr J, Derrick B . Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo. J Neurophysiol. 2002; 87(2):669-78. DOI: 10.1152/jn.00938.2000. View

Decoteau W, Kesner R . A double dissociation between the rat hippocampus and medial caudoputamen in processing two forms of knowledge. Behav Neurosci. 2001; 114(6):1096-108. DOI: 10.1037//0735-7044.114.6.1096. View

Mankin E, Sparks F, Slayyeh B, Sutherland R, Leutgeb S, Leutgeb J . Neuronal code for extended time in the hippocampus. Proc Natl Acad Sci U S A. 2012; 109(47):19462-7. PMC: 3511087. DOI: 10.1073/pnas.1214107109. View

Lisman J, Grace A . The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron. 2005; 46(5):703-13. DOI: 10.1016/j.neuron.2005.05.002. View

10.

Tanila H . Hippocampal place cells can develop distinct representations of two visually identical environments. Hippocampus. 1999; 9(3):235-46. DOI: 10.1002/(SICI)1098-1063(1999)9:3<235::AID-HIPO4>3.0.CO;2-3. View

11.

Hoang L, Kesner R . Dorsal hippocampus, CA3, and CA1 lesions disrupt temporal sequence completion. Behav Neurosci. 2008; 122(1):9-15. DOI: 10.1037/0735-7044.122.1.9. View

12.

Treves A, Rolls E . Computational analysis of the role of the hippocampus in memory. Hippocampus. 1994; 4(3):374-91. DOI: 10.1002/hipo.450040319. View

13.

Breindl A, Derrick B, Rodriguez S, Martinez Jr J . Opioid receptor-dependent long-term potentiation at the lateral perforant path-CA3 synapse in rat hippocampus. Brain Res Bull. 1994; 33(1):17-24. DOI: 10.1016/0361-9230(94)90045-0. View

14.

Samsonovich A, McNaughton B . Path integration and cognitive mapping in a continuous attractor neural network model. J Neurosci. 1997; 17(15):5900-20. PMC: 6573219. View

15.

Kesner R, Hunsaker M, Ziegler W . The role of the dorsal CA1 and ventral CA1 in memory for the temporal order of a sequence of odors. Neurobiol Learn Mem. 2009; 93(1):111-6. DOI: 10.1016/j.nlm.2009.08.010. View

16.

Rogers J, Kesner R . Cholinergic modulation of the hippocampus during encoding and retrieval. Neurobiol Learn Mem. 2003; 80(3):332-42. DOI: 10.1016/s1074-7427(03)00063-7. View

17.

Howard M, Fotedar M, Datey A, Hasselmo M . The temporal context model in spatial navigation and relational learning: toward a common explanation of medial temporal lobe function across domains. Psychol Rev. 2005; 112(1):75-116. PMC: 1421376. DOI: 10.1037/0033-295X.112.1.75. View

18.

Hunsaker M, Allan K, Kesner R . Role of dCA3 efferents via the fimbria in the acquisition of a delay nonmatch to place task. Hippocampus. 2007; 17(6):494-502. DOI: 10.1002/hipo.20288. View

19.

Treves A, Rolls E . Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network. Hippocampus. 1992; 2(2):189-99. DOI: 10.1002/hipo.450020209. View

20.

Mehta M, Barnes C, McNaughton B . Experience-dependent, asymmetric expansion of hippocampal place fields. Proc Natl Acad Sci U S A. 1997; 94(16):8918-21. PMC: 23195. DOI: 10.1073/pnas.94.16.8918. View