Phenotypes and Endotypes of Severe Asthma in Children

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2013 Jun 7

PMID 23741231

Citations 4

Authors

Young Yoo

Affiliations

Soon will be listed here.

Abstract

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma can allow further modulation of the natural history of severe asthma and may provide the pathophysiologic rationale for appropriate management strategies.

Citing Articles

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Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort.

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