» Articles » PMID: 23730228

DILI: New Insights into Diagnosis and Management

Overview
Journal Curr Hepat Rep
Publisher Springer
Date 2013 Jun 5
PMID 23730228
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

Drug-induced liver injury continues to have a significant impact. With over 1000 drugs now registered as causing DILI, this form of liver injury is the most cited reason for withdrawal of a drug from the marketplace. Despite this, the diagnosis of DILI continues to rely on subjective measures and expert opinion with results that are both difficult to verify and reproduce. However, recent developments in DILI research may provide new insights to improve diagnosis and treatment in the future.

Citing Articles

Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination.

Tak J, Kim S Toxicol Res. 2023; 39(4):533-547.

PMID: 37779594 PMC: 10541383. DOI: 10.1007/s43188-023-00201-4.


Cathelicidin promotes liver repair after acetaminophen-induced liver injury in mice.

Zhai T, Zhang J, Zhang J, Liu B, Zhou Z, Liu F JHEP Rep. 2023; 5(4):100687.

PMID: 36923240 PMC: 10009536. DOI: 10.1016/j.jhepr.2023.100687.


The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

Barbier-Torres L, Iruzubieta P, Fernandez-Ramos D, C Delgado T, Taibo D, Guitierrez-de-Juan V Nat Commun. 2017; 8(1):2068.

PMID: 29233977 PMC: 5727217. DOI: 10.1038/s41467-017-01970-x.


Systematic Review on Chinese Herbal Medicine Induced Liver Injury.

Zhang P, Ye Y, Yang X, Jiao Y Evid Based Complement Alternat Med. 2016; 2016:3560812.

PMID: 27651817 PMC: 5019919. DOI: 10.1155/2016/3560812.


MicroRNAs in Drug-induced Liver Injury.

Li L, Wang D, Zen K J Clin Transl Hepatol. 2015; 2(3):162-9.

PMID: 26357624 PMC: 4521241. DOI: 10.14218/JCTH.2014.00015.

References
1.
Bond G . Acetaminophen protein adducts: a review. Clin Toxicol (Phila). 2008; 47(1):2-7. DOI: 10.1080/15563650801941831. View

2.
Lee W . Drug-induced hepatotoxicity. N Engl J Med. 2003; 349(5):474-85. DOI: 10.1056/NEJMra021844. View

3.
ODonohue J, Oien K, Donaldson P, Underhill J, Clare M, MacSween R . Co-amoxiclav jaundice: clinical and histological features and HLA class II association. Gut. 2000; 47(5):717-20. PMC: 1728095. DOI: 10.1136/gut.47.5.717. View

4.
Reuben A, Koch D, Lee W . Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010; 52(6):2065-76. PMC: 3992250. DOI: 10.1002/hep.23937. View

5.
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z . Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009; 106(11):4402-7. PMC: 2657429. DOI: 10.1073/pnas.0813371106. View