Gentamicin in Neonates at Risk for Sepsis - Peak Serum Concentrations Are Not Necessary

Overview

Journal Paediatr Child Health

Publisher Oxford University Press

Specialty Pediatrics

Date 2013 Jun 5

PMID 23730168

Citations 3

Authors

Luke F Reynolds

Timothy L Mailman

Douglas D McMillan

Affiliations

Soon will be listed here.

Abstract

Background: Serum gentamicin concentrations (GSCs) are frequently obtained before and after gentamicin administration to newborns with, or at high risk for, sepsis.

Objective: To determine whether performing a peak GSC assay when the trough GSC is within the guidelines for care would add clinically relevant information for health care workers.

Methods: A retrospective review of the IWK Health Centre (Halifax, Nova Scotia) laboratory database for peak and trough GSC for infants <28 days after birth was performed.

Results: Of 5253 paired samples of trough and peak GSCs, 3001 (57%) had trough GSCs ≤2 μg/mL. Of these, only nine (0.3%) had a peak GSC >10 μg/mL.

Conclusions: Performing a peak GSC measurement does not provide further clinically important data and increases patient morbidity and hospital costs.

Citing Articles

Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit.

Al-Sulaiti F, Alkhiyami D, Elmekaty E, Awaisu A, Kheir N, El-Zubair A J Pharm Policy Pract. 2024; 17(1):2375753.

PMID: 39011355 PMC: 11249166. DOI: 10.1080/20523211.2024.2375753.

Should gentamicin trough levels be routinely obtained in term neonates?.

Ibrahim J, Maffei D, El-Chaar G, Islam S, Ponnaiya S, Nayak A J Perinatol. 2016; 36(11):962-965.

PMID: 27537855 DOI: 10.1038/jp.2016.120.

Stochastic process pharmacodynamics: dose timing in neonatal gentamicin therapy as an example.

Radivoyevitch T, Siranart N, Hlatky L, Sachs R AAPS J. 2015; 17(2):447-56.

PMID: 25663652 PMC: 4365091. DOI: 10.1208/s12248-014-9715-3.

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