Nuclear Phosphatase PPM1G in Cellular Survival and Neural Development

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2013 Jun 1

PMID 23723158

Citations 15

Authors

William H Foster

Adam Langenbacher

Chen Gao

Jaunian Chen

Yibin Wang

Affiliations

Soon will be listed here.

Abstract

Background: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown.

Results: Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g(-/-) mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed in ppm1g(-/-) embryos associated with increased cell death in the neural epithelium. In zebrafish, loss of ppm1g also led to neural defects with aberrant neural marker gene expression. Primary fibroblasts from ppm1g(-/-) embryos failed to grow without immortalization while immortalized ppm1g(-/-) fibroblasts had increased cell death upon oxidative and genotoxic stress when compared to wild type fibroblasts.

Conclusions: Our in vivo and in vitro studies revealed a critical role for PPM1G in normal development and cell survival.

Citing Articles

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Zhang X, Wang H, Yuan Y, Zhang J, Yang J, Zhang L Int J Oncol. 2024; 65(5).

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PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation.

Wang P, Li Z, Kim S, Xu H, Huang H, Yang C Life Sci Alliance. 2024; 7(10).

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Clinical Value of PPM1G Gene in Survival Prognosis and Immune Infiltration of Hepatocellular Carcinoma.

Xiao Q, Cheng Z, Kuang W, Wu H, Luo X, Wang R Appl Bionics Biomech. 2022; 2022:8926221.

PMID: 35126665 PMC: 8816587. DOI: 10.1155/2022/8926221.

Metal dependent protein phosphatase PPM family in cardiac health and diseases.

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