Evidence of Association Between Hepatitis C Virus Genotype 2b and Nosocomial Transmissions in Hemodialysis Centers from Southern Brazil

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2013 May 30

PMID 23714239

Citations 7

Authors

Nayle Maria Oliveira da Silva

Fabiana Nunes Germano

Raul Andres Mendoza-Sassi

Hector Nicolas Seuanez

Marcelo Alves Soares

Ana Maria Barral de Martinez

Affiliations

Soon will be listed here.

Abstract

Background: Hepatitis C virus infection is a serious public health problem. Hemodialysis is considered one of the main risk factors of HCV infection, due to several invasive medical procedures and potential nosocomial transmission that patients with chronic renal failure (CRF) are continuously submitted. The aims of this study were to determine the prevalence of HCV and its genotypes in patients with CRF in hemodialysis units in southern Brazil.

Methods: Demographic data and risk factors for HCV transmission were collected and analyzed. These data were obtained from patients undergoing hemodialysis treatment from January 2009 to August 2010, on two dialysis units of Rio Grande, southern Brazil. Genotyping was carried out by sequencing analysis of HCV NS5b, core-E1 junction and 5'UTR genomic regions.

Results: One hundred fifty-nine patients under regular hemodialysis treatment were studied. HCV prevalence was 23.3%. HCV-infected patients had been on dialysis treatment for 91.9 months, a more prolonged period compared to HCV-negative patients (p = 0.001). While HCV genotypes 1b and 3a were identified as the most frequent strains, a surprisingly high proportion of genotype 2b was observed among patients in one of the dialysis centers compared to the general HCV-infected population of the same area. Hemodialysis treatment exposure time and healthcare working were associated with HCV infection.

Conclusions: Besides the efforts to minimize nosocomial transmission of HCV, some events of transmission are still evidenced in dialysis units.

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References

Schroter M, Feucht H, Schafer P, Zollner B, Laufs R . High percentage of seronegative HCV infections in hemodialysis patients: the need for PCR. Intervirology. 1997; 40(4):277-8. DOI: 10.1159/000150558. View

Yuki N, Ishida H, Inoue T, Tabata T, Matsushita Y, Kishimoto H . Reappraisal of biochemical hepatitis C activity in hemodialysis patients. J Clin Gastroenterol. 2000; 30(2):187-94. DOI: 10.1097/00004836-200003000-00012. View

Carneiro M, Martins R, Teles S, Silva S, Lopes C, Cardoso D . Hepatitis C prevalence and risk factors in hemodialysis patients in Central Brazil: a survey by polymerase chain reaction and serological methods. Mem Inst Oswaldo Cruz. 2001; 96(6):765-9. DOI: 10.1590/s0074-02762001000600003. View

Santana G, Cotrim H, Mota E, Parana R, Santana N, Lyra L . [Antibodies to hepatitis C virus in patients undergoing hemodialysis in Salvador, BA, Brazil]. Arq Gastroenterol. 2001; 38(1):24-31. DOI: 10.1590/s0004-28032001000100006. View

Yang C, Chang H, Chou C, Peng S . Isolation effectively prevents the transmission of hepatitis C virus in the hemodialysis unit. J Formos Med Assoc. 2003; 102(2):79-85. View

Silva L, Silva M, Lopes G, Rodart I, Costa F, Santana N . Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters. Rev Soc Bras Med Trop. 2006; 38(6):496-502. DOI: 10.1590/s0037-86822005000600010. View

Chen S, Morgan T . The natural history of hepatitis C virus (HCV) infection. Int J Med Sci. 2006; 3(2):47-52. PMC: 1415841. DOI: 10.7150/ijms.3.47. View

Sandres-Saune K, Deny P, Pasquier C, Thibaut V, Duverlie G, Izopet J . Determining hepatitis C genotype by analyzing the sequence of the NS5b region. J Virol Methods. 2003; 109(2):187-93. DOI: 10.1016/s0166-0934(03)00070-3. View

Rahnavardi M, Hosseini Moghaddam S, Alavian S . Hepatitis C in hemodialysis patients: current global magnitude, natural history, diagnostic difficulties, and preventive measures. Am J Nephrol. 2008; 28(4):628-40. DOI: 10.1159/000117573. View

10.

Svirtlih N, Delic D, Simonovic J, Jevtovic D, Dokic L, Gvozdenovic E . Hepatitis C virus genotypes in Serbia and Montenegro: the prevalence and clinical significance. World J Gastroenterol. 2007; 13(3):355-60. PMC: 4065888. DOI: 10.3748/wjg.v13.i3.355. View

11.

Hinrichsen H, Leimenstoll G, STEGEN G, Schrader H, Folsch U, Schmidt W . Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients. Gut. 2002; 51(3):429-33. PMC: 1773370. DOI: 10.1136/gut.51.3.429. View

12.

Pereira L, Martelli C, Moreira R, Merchan-Hamman E, Stein A, Cardoso M . Prevalence and risk factors of Hepatitis C virus infection in Brazil, 2005 through 2009: a cross-sectional study. BMC Infect Dis. 2013; 13:60. PMC: 3574834. DOI: 10.1186/1471-2334-13-60. View

13.

Wasley A, Alter M . Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Dis. 2000; 20(1):1-16. DOI: 10.1055/s-2000-9506. View

14.

Engel M, Malta F, Gomes M, Mello I, Pinho J, Ono-Nita S . Acute hepatitis C virus infection assessment among chronic hemodialysis patients in the Southwest Parana State, Brazil. BMC Public Health. 2007; 7:50. PMC: 1855320. DOI: 10.1186/1471-2458-7-50. View

15.

Khan S, Attaullah S, Ali I, Ayaz S, Naseemullah , Khan S . Rising burden of Hepatitis C Virus in hemodialysis patients. Virol J. 2011; 8:438. PMC: 3180426. DOI: 10.1186/1743-422X-8-438. View

16.

Barril G, Traver J . Decrease in the hepatitis C virus (HCV) prevalence in hemodialysis patients in Spain: effect of time, initiating HCV prevalence studies and adoption of isolation measures. Antiviral Res. 2003; 60(2):129-34. DOI: 10.1016/j.antiviral.2003.08.008. View

17.

Moreira R, Pinho J, Fares J, Oba I, Cardoso M, Saraceni C . Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies. Can J Microbiol. 2003; 49(8):503-7. DOI: 10.1139/w03-065. View

18.

Carneiro M, Teles S, Lampe E, Espirito-Santo M, Gouveia-Oliveira R, Reis N . Molecular and epidemiological study on nosocomial transmission of HCV in hemodialysis patients in Brazil. J Med Virol. 2007; 79(9):1325-33. DOI: 10.1002/jmv.20932. View

19.

Meyers C, Seeff L, Stehman-Breen C, Hoofnagle J . Hepatitis C and renal disease: an update. Am J Kidney Dis. 2003; 42(4):631-57. DOI: 10.1016/s0272-6386(03)00828-x. View

20.

Albuquerque A, Coelho M, Lopes E, Lemos M, Moreira R . Prevalence and risk factors of hepatitis C virus infection in hemodialysis patients from one center in Recife, Brazil. Mem Inst Oswaldo Cruz. 2005; 100(5):467-70. DOI: 10.1590/s0074-02762005000500003. View