Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2013 May 28

PMID 23710149

Citations 44

Authors

Jackson Roberto Guedes da Silva Almeida

Grasielly Rocha Souza

Juliane Cabral Silva

Sarah Raquel Gomes de Lima Saraiva

Raimundo Goncalves de Oliveira Junior

Jullyana de Souza Siqueira Quintans

Rosana de Souza Siqueira Barreto

Leonardo Rigoldi Bonjardim

Socrates Cabral de Holanda Cavalcanti

Lucindo Jose Quintans Jr

Affiliations

Soon will be listed here.

Abstract

Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.

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