Liver, Brain, and Heart Metallothionein Induction by Stress

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 1990 Aug 1

PMID 2370551

Citations 16

Authors

J Hidalgo

M Borras

J S Garvey

A Armario

Affiliations

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Abstract

To date, stress has been reported to induce metallothionein (MT) synthesis in the liver only. In the present experiment, the effects of food and water deprivation alone or of immobilization stress plus food and water deprivation on liver, brain, and heart MT have been studied in adult male rats. Liver and brain MT levels were increased by immobilization stress as soon as 6 h after the onset of stress. Eighteen hours of immobilization, which is accompanied by food and water deprivation, further increased liver and brain MT levels and significantly increased heart MT content. A specific effect of immobilization was evident in all three tissues, because the effect of food and water deprivation alone was significantly lower than that of immobilization plus starvation. Changes in MT apparently were not related to changes in cytosolic Zn.

Citing Articles

Metallothionein and stress combine to affect multiple organ systems.

Lynes M, Hidalgo J, Manso Y, Devisscher L, Laukens D, Lawrence D Cell Stress Chaperones. 2014; 19(5):605-11.

PMID: 24584987 PMC: 4147071. DOI: 10.1007/s12192-014-0501-z.

Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- β in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis.

Grubic-Kezele T, Blagojevic Zagorac G, Jakovac H, Domitrovic R, Milin C, Radosevic-Stasic B Clin Dev Immunol. 2014; 2013:750406.

PMID: 24489578 PMC: 3893782. DOI: 10.1155/2013/750406.

Metallothionein and brain inflammation.

Manso Y, Adlard P, Carrasco J, Vasak M, Hidalgo J J Biol Inorg Chem. 2011; 16(7):1103-13.

PMID: 21678079 DOI: 10.1007/s00775-011-0802-y.

Metallothioneins and brain injury: What transgenic mice tell us.

Hidalgo J Environ Health Prev Med. 2011; 9(3):87-94.

PMID: 21432316 PMC: 2723515. DOI: 10.1007/BF02898066.

Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats.

Helal G, Aleisa A, Helal O, Al-Rejaie S, Al-Yahya A, Al-Majed A Oxid Med Cell Longev. 2010; 2(1):26-35.

PMID: 20046642 PMC: 2763228. DOI: 10.4161/oxim.2.1.7901.