Activation and Regulation of the Inflammasomes

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2013 May 25

PMID 23702978

Citations 1441

Authors

Eicke Latz

T Sam Xiao

Andrea Stutz

Affiliations

Soon will be listed here.

Abstract

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

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