Angiopoietin-like 4 (Angptl4): A Glucocorticoid-dependent Gatekeeper of Fatty Acid Flux During Fasting

Overview

Journal Adipocyte

Specialties Cell Biology
Endocrinology
Physiology

Date 2013 May 24

PMID 23700531

Citations 23

Authors

Suneil K Koliwad

Nora E Gray

Jen-Chywan Wang

Affiliations

Soon will be listed here.

Abstract

Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase, Angptl4 stimulates intracellular adipocyte lipolysis. Fatty acid release by murine adipocytes following fasting or treatment with glucocorticoids or catecholamines is highly Angptl4-dependent. In fact, Angptl4 can directly stimulate cAMP-dependent PKA signaling and lipolysis when added to adipocytes. Here, we detail this novel Angptl4-dependent lipolytic regulatory mechanism and discuss its physiological and therapeutic implications.

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