Left Ventricular Reverse Remodeling After Transcatheter Aortic Valve Implantation: a Cardiovascular Magnetic Resonance Study

Overview

Journal J Cardiovasc Magn Reson

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Radiology

Date 2013 May 23

PMID 23692630

Citations 14

Authors

Alessio La Manna

Alessandra Sanfilippo

Davide Capodanno

Antonella Salemi

Alessandra Cadoni

Irene Cascone

Gesualdo Polizzi

Michele Figuera

Rosetta Pittala

Carmelo Privitera

Corrado Tamburino

Affiliations

Soon will be listed here.

Abstract

Background: In patients with severe aortic stenosis, left ventricular hypertrophy is associated with increased myocardial stiffness and dysfunction linked to cardiac morbidity and mortality. We aimed at systematically investigating the degree of left ventricular mass regression and changes in left ventricular function six months after transcatheter aortic valve implantation (TAVI) by cardiovascular magnetic resonance (CMR).

Methods: Left ventricular mass indexed to body surface area (LVMi), end diastolic volume indexed to body surface area (LVEDVi), left ventricular ejection fraction (LVEF) and stroke volume (SV) were investigated by CMR before and six months after TAVI in patients with severe aortic stenosis and contraindications for surgical aortic valve replacement.

Results: Twenty-sevent patients had paired CMR at baseline and at 6-month follow-up (N=27), with a mean age of 80.7±5.2 years. LVMi decreased from 84.5±25.2 g/m2 at baseline to 69.4±18.4 g/m2 at six months follow-up (P<0.001). LVEDVi (87.2±30.1 ml /m2vs 86.4±22.3 ml/m2; P=0.84), LVEF (61.5±14.5% vs 65.1±7.2%, P=0.08) and SV (89.2±22 ml vs 94.7±26.5 ml; P=0.25) did not change significantly.

Conclusions: Based on CMR, significant left ventricular reverse remodeling occurs six months after TAVI.

Citing Articles

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