The Influence of Genetic Polymorphisms in MDR1 Gene on Breast Cancer Risk Factors in Chinese

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2013 May 22

PMID 23690268

Citations 2

Authors

Yunhe Jia

Wenjing Tian

Shuai Sun

Peng Han

Weinan Xue

Mingqi Li

Yanlong Liu

Shixiong Jiang

Binbin Cui

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BC) is the most common cancer among women in the world. The human multidrug resistance 1 gene (MDR1) is potentially an important gene influencing the susceptibility to breast cancer. This study aimed to assess the association of MDR1 genetic polymorphisms with the susceptibility to BC. Overall, 353 BC patients and 360 cancer-free controls were enrolled. The clinical characteristics were summarized by questionnaires. The c.1564A > T genetic polymorphism was genotyped using created restriction site-polymerase chain reaction method. We found that no significant differences in the genotypic and allelic frequencies between BC patients and cancer-free controls. Furthermore, the distribution of BC patients' risk factors was not significantly different among AA, AT, and TT genotypes. Our findings indicate that the c.1564A > T genetic polymorphism is not significantly associated with the susceptibility to BC in Chinese Han populations.

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