The Effect Pathways Analysis in the Abdominal Aortic Aneurysms

Background: Abdominal aortic aneurysm (AAA) is a relatively common disease in elderly. Currently, only surgical treatment has been available for ruptured AAA. Thus, it is impressing to elucidate the molecular cellular mechanisms of AAA in order to develop the effective medications.

Aim: This study is to explore the significant pathways and crosstalk between them in response to AAA.

Methods: The crosstalk of pathways was analyzed based on PPI datasets and expression profiles.

Results: It was showed that significant pathways included Cytokine-cytokine receptor interaction (hsa04060), B cell receptor signaling pathway, Chemokine signaling pathway (hsa04062), Cell adhesion molecules (CAMs) (hsa04514), and Hematopoietic cell lineage (hsa04640), which were in accordance with Lenk's results. Further analysis indicated that Chemokine signaling pathway (Hsa04062) and Cytokine-cytokine receptor interaction (Hsa04060) were both connected with the Cell adhesion molecules (CAMs) (Hsa04514) through the signal transduction (GO:0007165). B cell receptor signaling pathway (Hsa04662) and Cytokine-cytokine receptor interaction (Hsa04060) were both connected with the Natural killer cell mediated cytotoxicity (Hsa04650) through the apoptosis (GO:0006915) and signal transduction (GO:0007165), respectively. These crosstalks seemed to exit according to previous reports. We hope our study could provide insights for abdominal aortic aneurysm mechanism to some extent.

Conclusions: We analyzed the significant pathways related with AAA through Sp and DAVID method. The results were in accordance with previous reports.