A General Strategy for Obtaining Biodegradable Polymer Shelled Microbubbles As Theranostic Devices

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2013 May 22

PMID 23689681

Citations 6

Authors

Sabrina Capece

Ester Chiessi

Roberta Cavalli

Pierangela Giustetto

Dmitry Grishenkov

Gaio Paradossi

Affiliations

Soon will be listed here.

Abstract

Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.

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Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.

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