Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Major Depression and Schizophrenia: a Systematic Review of Recent Meta-analyses

Overview

Journal Ann Med

Publisher Informa Healthcare

Specialty General Medicine

Date 2013 May 22

PMID 23687987

Citations 27

Authors

Cindy L Hovington

Alexander McGirr

Martin Lepage

Marcelo T Berlim

Affiliations

Soon will be listed here.

Abstract

Background: In recent years, repetitive transcranial magnetic stimulation (rTMS) has been developed for the treatment of major depression (MD) and schizophrenia. Although rTMS has shown some promising findings, the lack of standardization in the methodology employed has resulted in discordant findings.

Objectives: The objective of this systematic review was to summarize several meta-analytical studies exploring the efficacy of rTMS in either MD or schizophrenia in order to examine the methodologies that increase the efficacy of rTMS and to provide some recommendations for future studies.

Methods: We searched the MEDLINE database for potentially relevant meta-analytic studies on the use of rTMS for treating major depression and schizophrenia published from January 2000 to October 2011.

Results: Fifteen rTMS meta-analytical studies were reviewed (11 on MD and 5 on schizophrenia). Several variables were reviewed including outcome measures, side-effects of rTMS, site of stimulation, frequency and intensity of stimulation, and number of treatment sessions.

Conclusions: Overall, rTMS appears to be an effective and promising therapeutic for both MD and schizophrenia.

Citing Articles

Repetitive transcranial magnetic stimulation enhanced by neuronavigation in the treatment of depressive disorder and schizophrenia.

Wang X, Zhang Y, Mu R, Cui L, Wang H World J Psychiatry. 2024; 14(11):1618-1622.

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Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.

Xie Y, Li C, Guan M, Zhang T, Ma C, Wang Z Hum Brain Mapp. 2024; 45(3):e26614.

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Rich-club reorganization of white matter structural network in schizophrenia patients with auditory verbal hallucinations following 1 Hz rTMS treatment.

Guan M, Xie Y, Li C, Zhang T, Ma C, Wang Z Neuroimage Clin. 2023; 40:103546.

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Self-Regulatory Neuronal Mechanisms and Long-Term Challenges in Schizophrenia Treatment.

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A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia.

Zhang X, Yang X, Shi Z, Xu R, Tan J, Yang J J Pers Med. 2023; 13(3).

PMID: 36983667 PMC: 10057590. DOI: 10.3390/jpm13030485.