NanoSIMS Multi-element Imaging Reveals Internalisation and Nucleolar Targeting for a Highly-charged Polynuclear Platinum Compound

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2013 May 21

PMID 23687657

Citations 23

Authors

Louise E Wedlock

Matt R Kilburn

Rong Liu

Jeremy A Shaw

Susan J Berners-Price

Nicholas P Farrell

Affiliations

Soon will be listed here.

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

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