Pepsin and Bile Acid Concentrations in Sputum of Mustard Gas Exposed Patients

Overview

Journal Saudi J Gastroenterol

Specialty Gastroenterology

Date 2013 May 18

PMID 23680709

Citations 1

Authors

Ashraf Karbasi

Hassan Goosheh

Rasoul Aliannejad

Hamid Saber

Maryam Salehi

Mahvash Jafari

Saber Imani

Amin Saburi

Mostafa Ghanei

Affiliations

Soon will be listed here.

Abstract

Background/aim: Gastro-esophageal reflux has been suggested to be associated with several pulmonary complications such as asthma, and post-transplant bronchiolitis obliterans (BO). Pepsin or bile salts in the sputum is shown to be an optimal molecular marker of gastric contents macro/micro aspiration. In this study, we investigated sputum pepsin as a marker of micro-aspiration in sulfur mustard (SM) exposed cases compared to healthy controls.

Materials And Methods: In a case controlled study, 26 cases with BO and 12 matched healthy controls were recruited and all cases were symptomatic and their exposure to SM was previously documented during Iran-Iraq conflict. Pepsin levels in sputum and total bile acids were measured using enzymatic assay. The severity of respiratory disorder was categorized based upon the spirometric values.

Result: The average concentration of pepsin in sputum was higher in the case group (0.29 ± 0.23) compared with healthy subjects (0.13 ± 0.07; P ± 0.003). Moreover, the average concentration of bile acids in the sputum cases was not significantly different in comparison to the controls ( P = 0.5).

Conclusion: Higher pepsin concentrations in sputum of SM exposed patients compared with healthy control subjects indicate the occurrence of significantly more gastric micro-aspiration in SM exposed patients.

Citing Articles

Mustard vesicant-induced lung injury: Advances in therapy.

Weinberger B, Malaviya R, Sunil V, Venosa A, Heck D, Laskin J Toxicol Appl Pharmacol. 2016; 305():1-11.

PMID: 27212445 PMC: 5119915. DOI: 10.1016/j.taap.2016.05.014.

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