Anti-Neutrophil Cytoplasmic Antibody in Behçet's Disease

Overview

Journal Int J Biomed Sci

Specialty General Medicine

Date 2013 May 16

PMID 23674967

Citations 2

Authors

Nursen Duzgun

Mehmet Sahin

Ergin Ayaslioglu

Affiliations

Soon will be listed here.

Abstract

Anti neutrophil cytoplasmic antibody (ANCA) is strongly associated with some vasculitic disorders. Behçet's disease (BD) is a systemic vasculitis of unknown etiology. In this study, ANCA was found to be positive in 8 out of 66 patients (10.2%) with BD by combination testing consisting of immunofluorescence and ELISA [one patient showed an atypical pattern by indirect immunofloresence techique, 6 patients were reactive to bacterial-permeability increasing protein (BPI) and one patient was reactive to Cathepsin G in ELISA]. There were no vascular manifestations such as veneous or arterial thrombosis and arterial aneurysms in ANCA-positive patients with BD. The results suggest that ANCA may be found in a minority of BD as those in previous published studies.

Citing Articles

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Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease.

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