The Multiple Activities of BMPs During Spinal Cord Development

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2013 May 16

PMID 23673983

Citations 27

Authors

Gwenvael Le Dreau

Elisa Marti

Affiliations

Soon will be listed here.

Abstract

Bone morphogenetic proteins (BMPs) are one of the main classes of multi-faceted secreted factors that drive vertebrate development. A growing body of evidence indicates that BMPs contribute to the formation of the central nervous system throughout its development, from the initial shaping of the neural primordium to the generation and maturation of the different cell types that form the functional adult nervous tissue. In this review, we focus on the multiple activities of BMPs during spinal cord development, paying particular attention to recent results that highlight the complexity of BMP signaling during this process. These findings emphasize the unique capacity of these signals to mediate various functions in the same tissue throughout development, recruiting diverse effectors and strategies to instruct their target cells.

Citing Articles

Early spinal cord development: from neural tube formation to neurogenesis.

Saade M, Marti E Nat Rev Neurosci. 2025; .

PMID: 39915695 DOI: 10.1038/s41583-025-00906-5.

Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects.

Wang Y, Zhang K, Guo J, Yang S, Shi X, Pan J Adv Sci (Weinh). 2022; 10(4):e2204018.

PMID: 36504449 PMC: 9896034. DOI: 10.1002/advs.202204018.

Recent advances in understanding cell type transitions during dorsal neural tube development.

Kalcheim C, Rekler D Fac Rev. 2022; 11:27.

PMID: 36225209 PMC: 9523542. DOI: 10.12703/r/11-27.

Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling.

Rekler D, Kalcheim C Elife. 2022; 11.

PMID: 35394423 PMC: 8993216. DOI: 10.7554/eLife.72723.

BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time.

Le Dreau G Front Neurosci. 2022; 15:819990.

PMID: 35153664 PMC: 8829030. DOI: 10.3389/fnins.2021.819990.

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