Aripiprazole

Overview

Journal Profiles Drug Subst Excip Relat Methodol

Date 2013 May 15

PMID 23668402

Citations 3

Authors

Febry Ardiana

Maria L A D Lestari

Gunawan Indrayanto

Affiliations

Soon will be listed here.

Abstract

Aripiprazole is an atypical antipsychotic drug which belongs to the benzisoxazole derivatives. Aripiprazole is available in many salts and polymorphs forms. X-ray diffraction, IR spectroscopy, and DSC could be used for differentiating the polymorphs of aripiprazole. Some instrumental methods of analysis such as UV spectrophotometer, HPTLC, HPLC, and CE can be applied for analyzing aripiprazole and its impurities. Chromatography methods that have an MS/MS detector is the method of choice for analyzing aripiprazole and its metabolites. Bioavailability studies of the polymorphs of aripiprazole and their pharmaceutical preparations are very important to optimize the formulations of the dosage forms.

Citing Articles

The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods.

Lyszczarz E, Brniak W, Szafraniec-Szczesny J, Majka T, Majda D, Zych M Pharmaceutics. 2021; 13(8).

PMID: 34452083 PMC: 8401512. DOI: 10.3390/pharmaceutics13081122.

New Cocrystals of Antipsychotic Drug Aripiprazole: Decreasing the Dissolution through Cocrystallization.

Liu W, Ma R, Liang F, Duan C, Zhang G, Chen Y Molecules. 2021; 26(9).

PMID: 33919175 PMC: 8122301. DOI: 10.3390/molecules26092414.

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Interact With the Antipsychotics Risperidone and Aripiprazole.

Osuna-Luque J, Rodriguez-Ramos A, Gamez-Del-Estal M, Ruiz-Rubio M J Exp Neurosci. 2018; 12:1179069518798628.

PMID: 30245571 PMC: 6144587. DOI: 10.1177/1179069518798628.