Comparative Study of Secretin and Lundh Tests

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1975 Jun 1

PMID 236650

Citations 12

Authors

K Gyr

N M Agrawal

O FELSENFELD

R G Font

Affiliations

Soon will be listed here.

Abstract

Exocrine pancreatic function in 19 patients with pancreatic disease and in 14 of 16 controls was measured by secretin stimulation and by the Lundh test on two different occasions. Peak bicarbonate concentration in the Lundh test emerged as the most reliable parameters. No additional diagnostic value was obtained by measuring enzymes after secretin injection. In 6 patients with chronic and in 8 of 13 patients with acute pancreatitis, both tests gave results that agreed with each other. The remaining 5 patients showed either an abnormal secretin value or an abnormal Lundh test. This is consistent with the wide variation seen in acute pancreatitis. It is concluded that the Lundh test as well as the secretin test were of value in the assessment of chronic pancreatic disease. The secretin test may be slightly more sensitive to mild and acute pancreatic damage than is the Lundh test. However stimulation of the pancreas by a test meal is easier to perform and more economic.

Citing Articles

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.

Lew D, Afghani E, Pandol S Dig Dis Sci. 2017; 62(7):1702-1712.

PMID: 28501969 PMC: 5507364. DOI: 10.1007/s10620-017-4602-2.

Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update.

Jantratid E, Janssen N, Reppas C, Dressman J Pharm Res. 2008; 25(7):1663-76.

PMID: 18404251 DOI: 10.1007/s11095-008-9569-4.

Chronic pancreatitis: diagnosis and treatment.

Sidhu S, Tandon R Postgrad Med J. 1996; 72(848):327-33.

PMID: 8758008 PMC: 2398476. DOI: 10.1136/pgmj.72.848.327.

Exocrine pancreatic function tests.

Lankisch P Gut. 1982; 23(9):777-98.

PMID: 7049860 PMC: 1419754. DOI: 10.1136/gut.23.9.777.

Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 2. Tests of pancreatic secretion.

Boyd E, Wormsley K Int J Pancreatol. 1987; 2(4):211-21.

PMID: 3316433 DOI: 10.1007/BF02788399.

References

LUNDH G . DIAGNOSTIC INVESTIGATION OF THE EXTERNAL PANCREATIC SECRETION. Bull Soc Int Chir. 1965; 24:169-205. View

Lurie B, Brom B, Bank S, Novis B, Marks I . Comparative response of exocrine pancreatic secretion following a test meal and secretin-pancreozymin stimulation. Scand J Gastroenterol. 1973; 8(1):27-32. View

ZIEVE L, Silvis S, Mulford B, BLACKWOOD W . Secretion of pancreatic enzymes. I. Response to secretin and pancreozymin. Am J Dig Dis. 1966; 11(9):671-84. DOI: 10.1007/BF02239420. View

SCHOEN H, RICO-IRLES J, Henning N . [On research on the excretory pancreas function. II. Comparative studies on pancreas-stimulating agents]. Klin Wochenschr. 1962; 40:15-8. DOI: 10.1007/BF01483444. View

ZIEVE L, Mulford B, McHale A . Secretion of pancreatic enzymes. II. Comparative response following test meal or injection of secretin and pancreozymin. Am J Dig Dis. 1966; 11(9):685-94. DOI: 10.1007/BF02239421. View

Sun D . THE USE OF PANCREOZYMIN-SECRETIN TEST IN THE DIAGNOSIS OF PANCREATITIS AND TUMORS OF THE PANCREAS. Gastroenterology. 1963; 45:203-8. View

COOK H, Lennard-Jones J, Sherif S, Wiggins H . Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease. Gut. 1967; 8(4):408-14. PMC: 1552540. DOI: 10.1136/gut.8.4.408. View

Fiore E, Dal Monte P, Sasdelli M . [Comparative study of exocrine pancreatic secretion after stimulation with pancreozymin and secretin and after a test meal]. G Clin Med. 1967; 48(11):1194-203. View

Burton P, Evans D, Harper A, HOWATH T, OLEESKY S, Scott J . A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut. 1960; 1:111-24. PMC: 1413219. DOI: 10.1136/gut.1.2.111. View

10.

Hartley R, GAMBILL E, ENGSTROM G, Summerskill H . Pancreatic exocrine function. Comparison of responses to augmented secretin stimulus, augmented pancreozymin stimulus, and test meal in health and disease. Am J Dig Dis. 1966; 11(1):27-39. DOI: 10.1007/BF02237668. View

11.

DREILING D . The early diagnosis of pancreatic cancer. Scand J Gastroenterol Suppl. 1970; 6:115-22. View

12.

Worning H . The pancreatic secretion of amylase as compared to the amylase concentration in the intestinal contents after ingestion of a meal. Scand J Gastroenterol. 1971; 6(3):257-60. DOI: 10.3109/00365527109180704. View

13.

DREILING D, Greenstein A, Bordalo O . The hypersecretory states of the pancreas. Implications in the pathophysiology of pancreatic inflammation and the pathogenesis of peptic ulcer diathesis. Am J Gastroenterol. 1973; 59(6):505-11. View

14.

Wiggins H . Simple method for estimating trypsin. Gut. 1967; 8(4):415-6. PMC: 1552536. DOI: 10.1136/gut.8.4.415. View

15.

LUNDH G . Pancreatic exocrine function in neoplastic and inflammatory disease; a simple and reliable new test. Gastroenterology. 1962; 42:275-80. View

16.

Kayasseh L, Stalder G . [Diagnosis of pancreatic insufficiency. Experience with the Lundh test]. Schweiz Med Wochenschr. 1971; 101(45):1624-8. View

17.

Moeller D, DUNN G, KLOTZ A . Comparison of the pancreozymin-secretin test and the Lundh test meal. Am J Dig Dis. 1972; 17(9):799-805. DOI: 10.1007/BF02231150. View