Aquaporin 4 Molecular Mimicry and Implications for Neuromyelitis Optica

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2013 May 14

PMID 23664693

Citations 16

Authors

Radhika A Vaishnav

Ruolan Liu

Joab Chapman

Andrew M Roberts

Hong Ye

Jovan D Rebolledo-Mendez

Takeshi Tabira

Alicia H Fitzpatrick

Anat Achiron

Mark P Running

Robert P Friedland

Affiliations

Soon will be listed here.

Abstract

Neuromyelitis optica (NMO) is associated with antibodies to aquaporin 4 (AQP4). We hypothesized that antibodies to AQP4 can be triggered by exposure to environmental proteins. We compared human AQP4 to plant and bacterial proteins to investigate the occurrence of significantly similar structures and sequences. High similarity to a known epitope for NMO-IgG, AQP4(207-232), was observed for corn ZmTIP4-1. NMO and non-NMO sera were assessed for reactivity to AQP4(207-232) and the corn peptide. NMO patient serum showed reactivity to both peptides as well as to plant tissue. These findings warrant further investigation into the role of the environment in NMO etiology.

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