Emerging Moxifloxacin Resistance in Pseudomonas Aeruginosa Keratitis Isolates in South India

Overview

Journal Ophthalmic Epidemiol

Publisher Informa Healthcare

Specialties Ophthalmology
Public Health

Date 2013 May 14

PMID 23662986

Citations 21

Authors

Catherine E Oldenburg

Prajna Lalitha

Muthiah Srinivasan

Revathi Rajaraman

Meenakshi Ravindran

Jeena Mascarenhas

Durga S Borkar

Kathryn J Ray

Michael E Zegans

Stephen D McLeod

Travis C Porco

Thomas M Lietman

Nisha R Acharya

Affiliations

Soon will be listed here.

Abstract

Purpose: To describe temporal trends in Pseudomonas aeruginosa resistance to moxifloxacin in keratitis isolates from South India.

Methods: The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial assessing outcomes in patients with culture positive bacterial corneal ulcers randomized to receive prednisolone phosphate or placebo. All patients received moxifloxacin, and susceptibility to moxifloxacin was measured at baseline using Etest. We investigated trends in moxifloxacin susceptibility of P. aeruginosa during 2007, 2008, and 2009 isolated in SCUT in South India.

Results: There were 89 P. aeruginosa isolates during 2007, 2008, and 2009 in SCUT that were eligible for this study. There was an increase in the proportion of resistant isolates from 19% in 2007 to 52% in 2009 (p = 0.02, χ(2) test for trend). Logistic regression showed that there was a 2-fold increase in odds of resistance per 1 year increase during the study period (odds ratio 2.16, 95% confidence interval 1.09-4.26, p = 0.027).

Conclusions: We found a sharp increase in the proportion of isolates that were resistant to moxifloxacin from 2007 to 2009. Further work needs to be done to characterize the nature of this increase.

Citing Articles

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The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study.

Khor W, Lakshminarayanan R, Periayah M, Prajna V, Garg P, Sharma N Int Ophthalmol. 2024; 44(1):361.

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and P infectious keratitis: key bacterial mechanisms that mediate pathogenesis and emerging therapeutics.

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PMID: 37671149 PMC: 10475732. DOI: 10.3389/fcimb.2023.1250257.

Antimicrobial resistance in topical treatments for microbial keratitis: protocol for a systematic review and meta-analysis.

Tuft S, Evans J, Gordon I, Leck A, Stone N, Neal T BMJ Open. 2023; 13(3):e069338.

PMID: 36882242 PMC: 10008341. DOI: 10.1136/bmjopen-2022-069338.

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