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After the Revolution? Ethical and Social Challenges in 'personalized Genomic Medicine'

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Journal Per Med
Date 2013 May 11
PMID 23662108
Citations 19
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Abstract

Personalized genomic medicine (PGM) is a goal that currently unites a wide array of biomedical initiatives, and is promoted as a 'new paradigm for healthcare' by its champions. Its promissory virtues include individualized diagnosis and risk prediction, more effective prevention and health promotion, and patient empowerment. Beyond overcoming scientific and technological hurdles to realizing PGM, proponents may interpret and rank these promises differently, which carries ethical and social implications for the realization of PGM as an approach to healthcare. We examine competing visions of PGM's virtues and the directions in which they could take the field, in order to anticipate policy choices that may lie ahead for researchers, healthcare providers and the public.

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References
1.
Guttmacher A, Collins F, Carmona R . The family history--more important than ever. N Engl J Med. 2004; 351(22):2333-6. DOI: 10.1056/NEJMsb042979. View

2.
Whitehouse P, Juengst E . Antiaging medicine and mild cognitive impairment: practice and policy issues for geriatrics. J Am Geriatr Soc. 2005; 53(8):1417-22. DOI: 10.1111/j.1532-5415.2005.53411.x. View

3.
Post S . Preventing schizophrenia and Alzheimer disease: comparative ethics. Schizophr Res. 2001; 51(1):103-8. DOI: 10.1016/s0920-9964(01)00246-8. View

4.
Powell K, Christianson C, Cogswell W, Dave G, Verma A, Eubanks S . Educational needs of primary care physicians regarding direct-to-consumer genetic testing. J Genet Couns. 2011; 21(3):469-78. DOI: 10.1007/s10897-011-9471-9. View

5.
Taylor P . Personal genomes: when consent gets in the way. Nature. 2008; 456(7218):32-3. DOI: 10.1038/456032a. View