Antioxidants and Diabetic Retinopathy

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2013 May 8

PMID 23649947

Citations 19

Authors

Michael Williams

Ruth E Hogg

Usha Chakravarthy

Affiliations

Soon will be listed here.

Abstract

The biochemical perturbations in diabetes mellitus (DM) create the conditions for the production of free radicals, the consequence of which is increased oxidative stress. Evidence has accrued over the past 2 decades that suggests that oxidative stress is an important pathogenetic factor in the development of diabetic retinopathy (DR). Experimental data show that the use of strategies that ameliorate oxidative stress can prevent and retard the development of DR in the animal model. Clinical observations also suggest that reducing oxidative stress may help to reverse pathological manifestations of DR. The present article constitutes an examination of the role of antioxidants in the management of DR and the current state of clinically relevant knowledge.

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