Long Noncoding RNAs in Biology and Hematopoiesis

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2013 May 7

PMID 23645840

Citations 33

Authors

Vikram R Paralkar

Mitchell J Weiss

Affiliations

Soon will be listed here.

Abstract

Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes, including epigenetic control of transcription, mRNA stability, and protein localization. Although little is known about lncRNAs in hematopoiesis, they are likely to exert widespread roles in this process.

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