Risk of Adult Acute and Chronic Myeloid Leukemia with Cigarette Smoking and Cessation

Overview

Journal Cancer Epidemiol

Publisher Elsevier

Specialties Oncology
Public Health

Date 2013 May 7

PMID 23643192

Citations 20

Authors

Jessica R B Musselman

Cindy K Blair

James R Cerhan

Phuong Nguyen

Betsy Hirsch

Julie A Ross

Affiliations

Soon will be listed here.

Abstract

Background: Cigarette smoking is an established risk factor for adult myeloid leukemia, particularly acute myeloid leukemia (AML), but less is known about the nature of this association and effects of smoking cessation on risk.

Methods: In a large population-based case-control study of myeloid leukemia that included 414 AML and 185 chronic myeloid leukemia (CML) cases and 692 controls ages 20-79 years, we evaluated risk associated with cigarette smoking and smoking cessation using unconditional logistic regression methods and cubic spline modeling.

Results: AML and CML risk increased with increasing cigarette smoking intensity in men and women. A monotonic decrease in AML risk was observed with increasing time since quitting, whereas for CML, the risk reduction was more gradual. For both AML and CML, among long-term quitters (≥30 years), risk was comparable to non-smokers.

Conclusions: Our study confirms the increased risk of myeloid leukemia with cigarette smoking and provides encouraging evidence of risk attenuation following cessation.

Citing Articles

Higher prevalence of harbouring BCR::ABL1 in first-degree relatives of chronic myeloid leukaemia (CML) patients compared to normal population.

Kuan J, Su A, Sim S, Tay S BMC Cancer. 2024; 24(1):734.

PMID: 38877512 PMC: 11179337. DOI: 10.1186/s12885-024-12102-2.

Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility.

Vincent M, Fitch S, Bylsma L, Thompson C, Rogers S, Britt J Toxicol Sci. 2024; 199(2):172-193.

PMID: 38547404 PMC: 11131035. DOI: 10.1093/toxsci/kfae039.

The Global Burden of Leukemia and Its Attributable Factors in 204 Countries and Territories: Findings from the Global Burden of Disease 2019 Study and Projections to 2030.

Du M, Chen W, Liu K, Wang L, Hu Y, Mao Y J Oncol. 2022; 2022:1612702.

PMID: 35509847 PMC: 9061017. DOI: 10.1155/2022/1612702.

Magnitude and Temporal Trend of the Chronic Myeloid Leukemia: On the Basis of the Global Burden of Disease Study 2019.

Hu Y, Li Q, Hou M, Peng J, Yang X, Xu S JCO Glob Oncol. 2021; 7:1429-1441.

PMID: 34591599 PMC: 8492379. DOI: 10.1200/GO.21.00194.

Chronic myelogenous leukemia occurring in two brothers: The opposite sides of the same coin?.

Verrou E, Tsirou K, Karampatzakis N, Triantafyllou T, Sevastoudi A, Grigoriadou G Leuk Res Rep. 2021; 16:100261.

PMID: 34401318 PMC: 8358150. DOI: 10.1016/j.lrr.2021.100261.

References

Bjork J, Johansson B, Broberg K, Albin M . Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: a case-control study. Leuk Res. 2008; 33(6):788-91. DOI: 10.1016/j.leukres.2008.10.009. View

Kasim K, Levallois P, Abdous B, Auger P, Johnson K . Lifestyle factors and the risk of adult leukemia in Canada. Cancer Causes Control. 2005; 16(5):489-500. DOI: 10.1007/s10552-004-7115-1. View

Kane E, Roman E, Cartwright R, Parker J, MORGAN G . Tobacco and the risk of acute leukaemia in adults. Br J Cancer. 1999; 81(7):1228-33. PMC: 2374333. DOI: 10.1038/sj.bjc.6690833. View

Vardiman J, Lee Harris N, Brunning R . The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002; 100(7):2292-302. DOI: 10.1182/blood-2002-04-1199. View

. Cigarette smoking among adults--United States, 2006. MMWR Morb Mortal Wkly Rep. 2007; 56(44):1157-61. View

Severson R, Davis S, Heuser L, Daling J, Thomas D . Cigarette smoking and acute nonlymphocytic leukemia. Am J Epidemiol. 1990; 132(3):418-22. DOI: 10.1093/oxfordjournals.aje.a115676. View

Bjork J, Albin M, Mauritzson N, Stromberg U, Johansson B, Hagmar L . Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations. Leuk Res. 2001; 25(10):865-72. DOI: 10.1016/s0145-2126(01)00048-0. View

Friedman G . Cigarette smoking, leukemia, and multiple myeloma. Ann Epidemiol. 1993; 3(4):425-8. DOI: 10.1016/1047-2797(93)90071-b. View

Bjork J, Albin M, Welinder H, Tinnerberg H, Mauritzson N, Kauppinen T . Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?. Occup Environ Med. 2001; 58(11):722-7. PMC: 1740065. DOI: 10.1136/oem.58.11.722. View

10.

Bacher U, Kern W, Schnittger S, Hiddemann W, Schoch C, Haferlach T . Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: a study on 2,235 patients. Ann Hematol. 2005; 84(12):785-91. DOI: 10.1007/s00277-005-1099-0. View

11.

. State-specific prevalence of cigarette smoking and smokeless tobacco use among adults --- United States, 2009. MMWR Morb Mortal Wkly Rep. 2010; 59(43):1400-6. View

12.

Brownson R, Novotny T, Perry M . Cigarette smoking and adult leukemia. A meta-analysis. Arch Intern Med. 1993; 153(4):469-75. View

13.

Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, Gao Y . Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst. 2004; 96(2):99-106. DOI: 10.1093/jnci/djh014. View

14.

Wong O, Harris F, Yiying W, Hua F . A hospital-based case-control study of acute myeloid leukemia in Shanghai: analysis of personal characteristics, lifestyle and environmental risk factors by subtypes of the WHO classification. Regul Toxicol Pharmacol. 2009; 55(3):340-52. DOI: 10.1016/j.yrtph.2009.08.007. View

15.

Slattery M, Edwards S, Caan B, Kerber R, Potter J . Response rates among control subjects in case-control studies. Ann Epidemiol. 1995; 5(3):245-9. DOI: 10.1016/1047-2797(94)00113-8. View

16.

Brownson R, Chang J, Davis J . Cigarette smoking and risk of adult leukemia. Am J Epidemiol. 1991; 134(9):938-41. DOI: 10.1093/oxfordjournals.aje.a116177. View

17.

Sandler D, Shore D, ANDERSON J, Davey F, Arthur D, Mayer R . Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow. J Natl Cancer Inst. 1993; 85(24):1994-2003. DOI: 10.1093/jnci/85.24.1994. View

18.

Richardson D, Terschuren C, Pohlabeln H, Jockel K, Hoffmann W . Temporal patterns of association between cigarette smoking and leukemia risk. Cancer Causes Control. 2007; 19(1):43-50. DOI: 10.1007/s10552-007-9068-7. View

19.

Vardiman J . The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms. Chem Biol Interact. 2009; 184(1-2):16-20. DOI: 10.1016/j.cbi.2009.10.009. View

20.

Kroll M, Murphy F, Pirie K, Reeves G, Green J, Beral V . Alcohol drinking, tobacco smoking and subtypes of haematological malignancy in the UK Million Women Study. Br J Cancer. 2012; 107(5):879-87. PMC: 3425977. DOI: 10.1038/bjc.2012.333. View