Immunosenescence and Organ Transplantation

Overview

Journal Transplant Rev (Orlando)

Specialty General Surgery

Date 2013 May 4

PMID 23639337

Citations 24

Authors

Timm Heinbokel

Abdallah Elkhal

Guangxiang Liu

Karoline Edtinger

Stefan G Tullius

Affiliations

Soon will be listed here.

Abstract

Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation. Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation.

Citing Articles

Editorial: Immunosenescence in organ transplantation.

Iske J, Zhou H Front Transplant. 2024; 3:1422358.

PMID: 38993765 PMC: 11235217. DOI: 10.3389/frtra.2024.1422358.

Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction.

Jallah B, Kuypers D Drugs Aging. 2024; 41(3):219-238.

PMID: 38386164 DOI: 10.1007/s40266-024-01100-5.

The Impact of T-cell Aging on Alloimmunity and Inflammaging.

Iske J, Dedeilia A, Xiao Y, Martin F, Emmert M, Sage P Transplantation. 2023; 108(3):634-642.

PMID: 37389638 PMC: 10756935. DOI: 10.1097/TP.0000000000004715.

Can We Predict Graft Intolerance Syndrome After Kidney Transplant Failure? External Validation of a Previously Developed Model.

Bunthof K, Saboerali K, van de Wetering J, Nurmohamed A, Bemelman F, Zuilen A Transpl Int. 2023; 36:11147.

PMID: 37213489 PMC: 10195885. DOI: 10.3389/ti.2023.11147.

Current perspective of immunomodulators for lung transplant.

Sharma D, Krishnan G, Sharma N, Chandrashekhar A Indian J Thorac Cardiovasc Surg. 2022; 38(5):497-505.

PMID: 36050971 PMC: 9424406. DOI: 10.1007/s12055-022-01388-1.

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