Limitations of SRTM, Logan Graphical Method, and Equilibrium Analysis for Measuring Transient Dopamine Release with [(11)C]raclopride PET

Overview

Journal Am J Nucl Med Mol Imaging

Date 2013 May 3

PMID 23638336

Citations 13

Authors

Jenna M Sullivan

Su Jin Kim

Kelly P Cosgrove

Evan D Morris

Affiliations

Soon will be listed here.

Abstract

Conventional PET methods to estimate [(11)C]raclopride binding potential (BP ND) assume that endogenous dopamine concentration does not change during the scan time. However, this assumption is purposely violated in studies using pharmacological or behavioral stimuli to invoke acute dopamine release. When the assumption of steady-state dopamine is violated, conventional analysis methods may produce biased or even unusable estimates of BP ND. To illustrate this problem, we examined the effect of scan duration on ΔBP ND estimated by three common analysis methods (simplified reference tissue model, Logan graphical reference method, and equilibrium analysis) applied to simulated and experimental single-scan activation studies. The activation - dopamine release - in both the simulated and experimental studies was brief. Simulations showed ΔBP ND to be highly dependent on the window of data used to determine BP ND in the activation state. A similar pattern was seen in the data from human smoking studies. No such pattern of ΔBP ND dependence on the window of data used was apparent in simulations where dopamine was held constant. The dependence of ΔBP ND on the duration of data analyzed illustrates the inability of conventional methods to reliably quantify short-lived increases in endogenous dopamine.

Citing Articles

Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?.

Morris E, Emvalomenos G, Hoye J, Meikle S J Nucl Med. 2024; 65(12):1824-1837.

PMID: 39448268 PMC: 11619587. DOI: 10.2967/jnumed.124.267494.

Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans.

Tomasi D, Manza P, Logan J, Shokri-Kojori E, Yonga M, Kroll D Commun Biol. 2023; 6(1):166.

PMID: 36765261 PMC: 9918528. DOI: 10.1038/s42003-023-04545-3.

Assessment of motion and model bias on the detection of dopamine response to behavioral challenge.

Levine M, Mandeville J, Calabro F, Izquierdo-Garcia D, Chonde D, Chen K J Cereb Blood Flow Metab. 2022; 42(7):1309-1321.

PMID: 35118904 PMC: 9207487. DOI: 10.1177/0271678X221078616.

Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.

Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N Nicotine Tob Res. 2022; 24(10):1597-1606.

PMID: 35100429 PMC: 9575980. DOI: 10.1093/ntr/ntac026.

Assessment of transient dopamine responses to smoked cannabis.

Calakos K, Liu H, Lu Y, Anderson J, Matuskey D, Nabulsi N Drug Alcohol Depend. 2021; 227:108920.

PMID: 34399137 PMC: 8464527. DOI: 10.1016/j.drugalcdep.2021.108920.

References

Muzic Jr R, Cornelius S . COMKAT: compartment model kinetic analysis tool. J Nucl Med. 2001; 42(4):636-45. View

Montgomery A, Lingford-Hughes A, Egerton A, Nutt D, Grasby P . The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study. Synapse. 2007; 61(8):637-45. DOI: 10.1002/syn.20419. View

Barrett S, Boileau I, Okker J, Pihl R, Dagher A . The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse. 2004; 54(2):65-71. DOI: 10.1002/syn.20066. View

Volkow N, Wang G, Fowler J, Tomasi D, Telang F . Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci U S A. 2011; 108(37):15037-42. PMC: 3174598. DOI: 10.1073/pnas.1010654108. View

Laruelle M, Iyer R, Zea-Ponce Y, MALISON R, Zoghbi S, Baldwin R . Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse. 1997; 25(1):1-14. DOI: 10.1002/(SICI)1098-2396(199701)25:1<1::AID-SYN1>3.0.CO;2-H. View

Brody A, Olmstead R, Abrams A, Costello M, Khan A, Kozman D . Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009; 66(9):898-901. PMC: 2763050. DOI: 10.1016/j.biopsych.2009.06.011. View

Brody A, London E, Olmstead R, Allen-Martinez Z, Shulenberger S, Costello M . Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Psychiatry Res. 2010; 183(3):218-24. PMC: 2947623. DOI: 10.1016/j.pscychresns.2009.06.004. View

Munro C, McCaul M, Oswald L, Wong D, Zhou Y, Brasic J . Striatal dopamine release and family history of alcoholism. Alcohol Clin Exp Res. 2006; 30(7):1143-51. DOI: 10.1111/j.1530-0277.2006.00130.x. View

Frey K, Ehrenkaufer R, Beaucage S, Agranoff B . Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor. J Neurosci. 1985; 5(2):421-8. PMC: 6565198. View

10.

Pontieri F, Tanda G, Orzi F, Di Chiara G . Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature. 1996; 382(6588):255-7. DOI: 10.1038/382255a0. View

11.

Lammertsma A, Hume S . Simplified reference tissue model for PET receptor studies. Neuroimage. 1996; 4(3 Pt 1):153-8. DOI: 10.1006/nimg.1996.0066. View

12.

Lassen N . Neuroreceptor quantitation in vivo by the steady-state principle using constant infusion or bolus injection of radioactive tracers. J Cereb Blood Flow Metab. 1992; 12(5):709-16. DOI: 10.1038/jcbfm.1992.101. View

13.

Yoder K, Wang C, Morris E . Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand. J Nucl Med. 2004; 45(5):903-11. View

14.

Brody A, Mandelkern M, Olmstead R, Scheibal D, Hahn E, Shiraga S . Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006; 63(7):808-16. PMC: 2873693. DOI: 10.1001/archpsyc.63.7.808. View

15.

Yoder K, Albrecht D, Kareken D, Federici L, Perry K, Patton E . Test-retest variability of [¹¹C]raclopride-binding potential in nontreatment-seeking alcoholics. Synapse. 2010; 65(7):553-61. PMC: 3077540. DOI: 10.1002/syn.20874. View

16.

Houston G, Hume S, Hirani E, Goggi J, Grasby P . Temporal characterisation of amphetamine-induced dopamine release assessed with [11C]raclopride in anaesthetised rodents. Synapse. 2003; 51(3):206-12. DOI: 10.1002/syn.10296. View

17.

Normandin M, Schiffer W, Morris E . A linear model for estimation of neurotransmitter response profiles from dynamic PET data. Neuroimage. 2011; 59(3):2689-99. PMC: 3702051. DOI: 10.1016/j.neuroimage.2011.07.002. View

18.

Brody A, Olmstead R, London E, Farahi J, Meyer J, Grossman P . Smoking-induced ventral striatum dopamine release. Am J Psychiatry. 2004; 161(7):1211-8. DOI: 10.1176/appi.ajp.161.7.1211. View

19.

Endres C, Kolachana B, Saunders R, Su T, Weinberger D, Breier A . Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies. J Cereb Blood Flow Metab. 1997; 17(9):932-42. DOI: 10.1097/00004647-199709000-00002. View

20.

Varga J, Szabo Z . Modified regression model for the Logan plot. J Cereb Blood Flow Metab. 2002; 22(2):240-4. PMC: 2012949. DOI: 10.1097/00004647-200202000-00012. View