Nutritional Supplements and Plasma Antioxidants in Childhood Asthma

Overview

Journal Wien Klin Wochenschr

Publisher Springer

Specialty General Medicine

Date 2013 May 3

PMID 23636616

Citations 13

Authors

Elisabeth Fabian

Peter Poloskey

Lajos Kosa

Ibrahim Elmadfa

Lajos Attila Rethy

Affiliations

Soon will be listed here.

Abstract

Objective: This study investigated the relationship of plasma antioxidants to airway inflammation and systemic oxidative stress in children suffering from atopic asthma with consideration of the intake of nutritional supplements.

Subjects And Research Methods: A total of 35 asthmatic children (AG) and 21 healthy controls (CG) participated in this study. Plasma levels of vitamins A and E, β-carotene, coenzyme Q10 and malondialdehyde (MDA) were analyzed with high-performance liquid chromatography (HPLC); the total antioxidant capacity (TAC) was measured photometrically, and selenium was determined by atomic absorption spectroscopy (AAS). The volume of fractionated exhaled nitric oxide (FeNO) was measured with the NIOX nitric oxide monitoring system.

Results: The plasma antioxidants vitamins A and E, selenium, and coenzyme Q10 but not β-carotene were significantly (p < 0.05) lower in asthmatics than in controls. Further, asthmatic children had significantly reduced plasma concentrations of TAC (p < 0.01), significantly enhanced levels of MDA (p < 0.001), and exhaled a significantly (p < 0.001) higher mean volume of FENO than healthy children. Regular intake of supplements had a significant positive influence on plasma vitamin E (p < 0.01), selenium (p < 0.01), TAC (p < 0.05), MDA (p < 0.01), and FENO (p < 0.01) in asthmatics but not in controls. Additionally, significant negative associations of vitamin E and MDA (AG: p < 0.01; CG: p < 0.05), and vitamin E and FENO (AG: p < 0.05; CG: p > 0.05) were identified.

Conclusion: These results indicate that nutritional supplements beneficially modulate plasma antioxidants and thus might have a positive influence on systemic redox balance and subsequently, pulmonary inflammation in asthmatic children.

Citing Articles

The Link Between Dysbiosis, Inflammation, Oxidative Stress, and Asthma-The Role of Probiotics, Prebiotics, and Antioxidants.

Kleniewska P, Pawliczak R Nutrients. 2025; 17(1.

PMID: 39796449 PMC: 11722634. DOI: 10.3390/nu17010016.

The Role of Vitamins in the Pathogenesis of Asthma.

Zajac D, Wojciechowski P Int J Mol Sci. 2023; 24(10).

PMID: 37239921 PMC: 10218465. DOI: 10.3390/ijms24108574.

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.

Peroni D, Hufnagl K, Comberiati P, Roth-Walter F Front Nutr. 2023; 9:1032481.

PMID: 36698466 PMC: 9869175. DOI: 10.3389/fnut.2022.1032481.

The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study.

Ding Z, Pang L, Chai H, Li F, Wu M Front Public Health. 2022; 10:1059195.

PMID: 36408054 PMC: 9670139. DOI: 10.3389/fpubh.2022.1059195.

Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma: a randomized, double-blind, placebo-controlled trial.

Yeh C, Shih C, Liu T, Chiou Y Sci Rep. 2022; 12(1):18150.

PMID: 36307493 PMC: 9616827. DOI: 10.1038/s41598-022-21527-3.

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