Chromatin Remodeling, DNA Damage Repair and Aging

Overview

Journal Curr Genomics

Publisher Bentham Science Publishers

Date 2013 May 2

PMID 23633913

Citations 31

Authors

Baohua Liu

Raymond Kh Yip

Zhongjun Zhou

Affiliations

Soon will be listed here.

Abstract

Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging syndromes together with normal aging have suggested that accumulated damages might lead to exhaustion of resources that are required for physiological functions and thus accelerate aging. In this manuscript, combining the present understandings and latest findings, we focus mainly on discussing the role of chromatin remodeling in the repair of DNA double-strand breaks (DSBs) and regulation of aging.

Citing Articles

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