Subclinical Hypothyroidism and Cardiovascular Risk: How to End the Controversy

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2013 May 2

PMID 23633199

Citations 9

Authors

Nicolas Rodondi

Douglas C Bauer

Affiliations

Soon will be listed here.

Citing Articles

Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder.

Li M, Wang X, Wang X, Zhang J, Zhang X BMC Geriatr. 2024; 24(1):15.

PMID: 38177993 PMC: 10768208. DOI: 10.1186/s12877-023-04584-9.

Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study.

Ortolani Jr P, Romaldini J, Guerra R, Portes E, Meireles G, Pimenta J Arch Endocrinol Metab. 2018; 62(4):410-415.

PMID: 30304104 PMC: 10118738. DOI: 10.20945/2359-3997000000054.

Pesticide Exposure and Thyroid Function in Elementary School Children Living in an Agricultural Area, Brebes District, Indonesia.

Suhartono S, Kartini A, Subagio H, Budiyono B, Utari A, Suratman S Int J Occup Environ Med. 2018; 9(3):137-144.

PMID: 29995019 PMC: 6466981. DOI: 10.15171/ijoem.2018.1207.

Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women.

Harada P, Buring J, Cook N, Cobble M, Kulkarni K, Mora S J Endocr Soc. 2017; 1(2):113-123.

PMID: 28580441 PMC: 5453652. DOI: 10.1210/js.2016-1085.

Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.

Rieben C, Segna D, da Costa B, Collet T, Chaker L, Aubert C J Clin Endocrinol Metab. 2016; 101(12):4945-4954.

PMID: 27689250 PMC: 6287525. DOI: 10.1210/jc.2016-2129.

References

Quinn T, Gussekloo J, Kearney P, Rodondi N, Stott D . Subclinical thyroid disorders. Lancet. 2012; 380(9839):335-6. DOI: 10.1016/S0140-6736(12)61242-2. View

Hak A, Pols H, Visser T, Drexhage H, Hofman A, Witteman J . Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000; 132(4):270-8. DOI: 10.7326/0003-4819-132-4-200002150-00004. View

Monzani F, Caraccio N, Kozakowa M, Dardano A, Vittone F, Virdis A . Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study. J Clin Endocrinol Metab. 2004; 89(5):2099-106. DOI: 10.1210/jc.2003-031669. View

Simmonds M, Higgins J, Stewart L, Tierney J, Clarke M, Thompson S . Meta-analysis of individual patient data from randomized trials: a review of methods used in practice. Clin Trials. 2005; 2(3):209-17. DOI: 10.1191/1740774505cn087oa. View

LeGrys V, Funk M, Lorenz C, Giri A, Jackson R, Manson J . Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women. J Clin Endocrinol Metab. 2013; 98(6):2308-17. PMC: 3667262. DOI: 10.1210/jc.2012-4065. View

Surks M, Ortiz E, Daniels G, Sawin C, Col N, Cobin R . Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228-38. DOI: 10.1001/jama.291.2.228. View

Ochs N, Auer R, Bauer D, Nanchen D, Gussekloo J, Cornuz J . Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med. 2008; 148(11):832-45. DOI: 10.7326/0003-4819-148-11-200806030-00225. View

Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver J . The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab. 2007; 92(5):1715-23. DOI: 10.1210/jc.2006-1869. View

Razvi S, Shakoor A, Vanderpump M, Weaver J, Pearce S . The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab. 2008; 93(8):2998-3007. DOI: 10.1210/jc.2008-0167. View

10.

Fatourechi V, Lankarani M, Schryver P, Vanness D, Long K, Klee G . Factors influencing clinical decisions to initiate thyroxine therapy for patients with mildly increased serum thyrotropin (5.1-10.0 mIU/L). Mayo Clin Proc. 2003; 78(5):554-60. DOI: 10.4065/78.5.554. View

11.

Hyland K, Arnold A, Lee J, Cappola A . Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study. J Clin Endocrinol Metab. 2012; 98(2):533-40. PMC: 3565111. DOI: 10.1210/jc.2012-2180. View

12.

Rodondi N, den Elzen W, Bauer D, Cappola A, Razvi S, Walsh J . Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010; 304(12):1365-74. PMC: 3923470. DOI: 10.1001/jama.2010.1361. View

13.

Gharib H, Tuttle R, Baskin H, Fish L, Singer P, McDermott M . Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. J Clin Endocrinol Metab. 2005; 90(1):581-5. DOI: 10.1210/jc.2004-1231. View

14.

Cappola A, Fried L, Arnold A, Danese M, Kuller L, Burke G . Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2006; 295(9):1033-41. PMC: 1387822. DOI: 10.1001/jama.295.9.1033. View

15.

Helfand M . Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2004; 140(2):128-41. DOI: 10.7326/0003-4819-140-2-200401200-00015. View

16.

Rodondi N, Newman A, Vittinghoff E, de Rekeneire N, Satterfield S, Harris T . Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med. 2005; 165(21):2460-6. DOI: 10.1001/archinte.165.21.2460. View

17.

Biondi B, Cooper D . The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2007; 29(1):76-131. DOI: 10.1210/er.2006-0043. View

18.

Gencer B, Collet T, Virgini V, Bauer D, Gussekloo J, Cappola A . Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation. 2012; 126(9):1040-9. PMC: 3884576. DOI: 10.1161/CIRCULATIONAHA.112.096024. View

19.

Rodondi N, Aujesky D, Vittinghoff E, Cornuz J, Bauer D . Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med. 2006; 119(7):541-51. DOI: 10.1016/j.amjmed.2005.09.028. View