Preparation and Double Michael Addition Reactions of a Synthetic Equivalent of the Nazarov Reagent
Overview
Chemistry
Affiliations
A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with α,β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indolo[2,3-a]quinolizidine lactams to give pentacyclic yohimbinone-type derivatives.
Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.
Webster C, Park H, Ennis A, Hong J Tetrahedron Lett. 2021; 71.
PMID: 34054153 PMC: 8153367. DOI: 10.1016/j.tetlet.2021.153055.
A Straightforward Synthesis of Functionalized -Perhydroisoquinolin-1-ones.
Arioli F, Perez M, Are C, Molins E, Bosch J, Amat M Molecules. 2019; 24(3).
PMID: 30717460 PMC: 6385050. DOI: 10.3390/molecules24030557.