Stress-induced Cardiomyopathy (Takotsubo)--broken Heart and Mind?

Overview

Journal Vasc Health Risk Manag

Publisher Dove Medical Press

Specialty Cardiology & Vascular Diseases

Date 2013 Apr 30

PMID 23626469

Citations 16

Authors

Bjorn Redfors

Yangzhen Shao

Elmir Omerovic

Affiliations

Soon will be listed here.

Abstract

Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy, is characterized by severe but potentially reversible regional left ventricular wall motion abnormalities, ie, akinesia, in the absence of explanatory angiographic evidence of a coronary occlusion. The typical pattern is that of an akinetic apex with preserved contractions in the base, but other variants are also common, including basal or midmyocardial akinesia with preserved apical function. The pathophysiology of SIC remains largely unknown but catecholamines are believed to play a pivotal role. The diverse array of triggering events that have been linked to SIC are arbitrarily categorized as either emotional or somatic stressors. These categories can be considered as different elements of a continuous spectrum, linked through the interface of neurology and psychiatry. This paper reviews our current knowledge of SIC, with focus on the intimate relationship between the brain and the heart.

Citing Articles

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Broken Heart Syndrome: Evolving Molecular Mechanisms and Principles of Management.

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Quantitative Lipidomic Analysis of Takotsubo Syndrome Patients' Serum.

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