Sleep and Synaptic Changes

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2013 Apr 30

PMID 23623392

Citations 17

Authors

Chiara Cirelli

Affiliations

Soon will be listed here.

Abstract

Several recent studies, using molecular, electrophysiological, or structural approaches, have investigated how synapses are affected by sleep, spontaneous wake, chronic sleep restriction, and acute sleep deprivation. Overall, the results have found that even a few hours of sleep or wake can modify the molecular composition of excitatory synapses, change their efficacy, and make synapses grow or shrink. Moreover, partial and total loss of sleep affect the ability of synapses to undergo long-term potentiation, an effect that may underlie some of the negative consequences of sleep deprivation on memory and other cognitive functions.

Citing Articles

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The prevalence of sleep loss and sleep disorders in young and old adults.

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Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity.

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References

Cirelli C, Huber R, Gopalakrishnan A, Southard T, Tononi G . Locus ceruleus control of slow-wave homeostasis. J Neurosci. 2005; 25(18):4503-11. PMC: 6725032. DOI: 10.1523/JNEUROSCI.4845-04.2005. View

Liu Z, Faraguna U, Cirelli C, Tononi G, Gao X . Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex. J Neurosci. 2010; 30(25):8671-5. PMC: 2903226. DOI: 10.1523/JNEUROSCI.1409-10.2010. View

McDermott C, Lahoste G, Chen C, Musto A, Bazan N, Magee J . Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci. 2003; 23(29):9687-95. PMC: 6740462. View

Yang G, Gan W . Sleep contributes to dendritic spine formation and elimination in the developing mouse somatosensory cortex. Dev Neurobiol. 2011; 72(11):1391-8. PMC: 3404222. DOI: 10.1002/dneu.20996. View

Qin Y, Zhu Y, Baumgart J, Stornetta R, Seidenman K, Mack V . State-dependent Ras signaling and AMPA receptor trafficking. Genes Dev. 2005; 19(17):2000-15. PMC: 1199571. DOI: 10.1101/gad.342205. View

Mongrain V, Hernandez S, Pradervand S, Dorsaz S, Curie T, Hagiwara G . Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep. 2010; 33(9):1147-57. PMC: 2938796. DOI: 10.1093/sleep/33.9.1147. View

Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper R, Auwerx J . Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci. 2012; 32(36):12506-17. PMC: 6621272. DOI: 10.1523/JNEUROSCI.2306-12.2012. View

Mackiewicz M, Shockley K, Romer M, Galante R, Zimmerman J, Naidoo N . Macromolecule biosynthesis: a key function of sleep. Physiol Genomics. 2007; 31(3):441-57. DOI: 10.1152/physiolgenomics.00275.2006. View

Cirelli C, Pompeiano M, Tononi G . Neuronal gene expression in the waking state: a role for the locus coeruleus. Science. 1996; 274(5290):1211-5. DOI: 10.1126/science.274.5290.1211. View

10.

Malenka R, Bear M . LTP and LTD: an embarrassment of riches. Neuron. 2004; 44(1):5-21. DOI: 10.1016/j.neuron.2004.09.012. View

11.

Rao Y, Liu Z, Borok E, Rabenstein R, Shanabrough M, Lu M . Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest. 2007; 117(12):4022-33. PMC: 2104495. DOI: 10.1172/JCI32829. View

12.

Bramham C, Maho C, Laroche S . Suppression of long-term potentiation induction during alert wakefulness but not during 'enhanced' REM sleep after avoidance learning. Neuroscience. 1994; 59(3):501-9. DOI: 10.1016/0306-4522(94)90172-4. View

13.

Vyazovskiy V, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G . Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci. 2008; 11(2):200-8. DOI: 10.1038/nn2035. View

14.

Killgore W . Effects of sleep deprivation on cognition. Prog Brain Res. 2010; 185:105-29. DOI: 10.1016/B978-0-444-53702-7.00007-5. View

15.

Chauvette S, Seigneur J, Timofeev I . Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity. Neuron. 2012; 75(6):1105-13. PMC: 3458311. DOI: 10.1016/j.neuron.2012.08.034. View

16.

Diekelmann S, Born J . The memory function of sleep. Nat Rev Neurosci. 2010; 11(2):114-26. DOI: 10.1038/nrn2762. View

17.

Ravassard P, Pachoud B, Comte J, Mejia-Perez C, Scote-Blachon C, Gay N . Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus. Sleep. 2009; 32(2):227-40. PMC: 2635587. DOI: 10.1093/sleep/32.2.227. View

18.

Winters B, Huang Y, Dong Y, Krueger J . Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex. Brain Res. 2011; 1420:1-7. PMC: 3205322. DOI: 10.1016/j.brainres.2011.08.078. View

19.

Harris J, Jolivet R, Attwell D . Synaptic energy use and supply. Neuron. 2012; 75(5):762-77. DOI: 10.1016/j.neuron.2012.08.019. View

20.

Caroni P, Donato F, Muller D . Structural plasticity upon learning: regulation and functions. Nat Rev Neurosci. 2012; 13(7):478-90. DOI: 10.1038/nrn3258. View