Family-based Association Mapping in Crop Species

Overview

Journal Theor Appl Genet

Publisher Springer

Specialty Genetics

Date 2013 Apr 27

PMID 23620001

Citations 9

Authors

Baohong Guo

Daolong Wang

Zhigang Guo

William D Beavis

Affiliations

Soon will be listed here.

Abstract

Identification of allelic variants associated with complex traits provides molecular genetic information associated with variability upon which both artificial and natural selections are based. Family-based association mapping (FBAM) takes advantage of linkage disequilibrium among segregating progeny within crosses and among parents to provide greater power than association mapping and greater resolution than linkage mapping. Herein, we discuss the potential adaption of human family-based association tests and quantitative transmission disequilibrium tests for use in crop species. The rapid technological advancement of next generation sequencing will enable sequencing of all parents in a planned crossing design, with subsequent imputation of genotypes for all segregating progeny. These technical advancements are easily adapted to mating designs routinely used by plant breeders. Thus, FBAM has the potential to be widely adopted for discovering alleles, common and rare, underlying complex traits in crop species.

Citing Articles

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Genetic mapping of QTLs controlling brown seed coat traits by genome resequencing in sesame ( L.).

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Strategies to Assure Optimal Trade-Offs Among Competing Objectives for the Genetic Improvement of Soybean.

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Genome-wide association study of seed coat color in sesame (Sesamum indicum L.).

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Relevance of genetic relationship in GWAS and genomic prediction.

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