Rap1 Signaling Prevents L-type Calcium Channel-dependent Neurotransmitter Release

Overview

Journal J Neurosci

Specialty Neurology

Date 2013 Apr 26

PMID 23616533

Citations 27

Authors

Jaichandar Subramanian

Louis Dye

Alexei Morozov

Affiliations

Soon will be listed here.

Abstract

The small GTPase Rap1 contributes to fear learning and cortico-amygdala plasticity by inhibiting glutamate release from cortical neurons, but mechanisms of this inhibition remain unknown. Conversely, L-type calcium channels (LTCCs) become involved in glutamate release after fear learning and LTP induction. Here, we show that Rap1 deletion in mouse primary cortical neurons increases synaptic vesicle exocytosis without altering endocytosis or vesicle pool size in an LTCC-dependent manner. We identify Erk1/2 as the downstream effector of Rap1 and show that its inhibition increases plasma membrane expression of LTCCs near presynaptic terminals. We propose that the Rap1 signaling enables plasticity and fear learning by regulating LTCCs at cortico-amygdala synapses.

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