Conjugated Polyelectrolyte Materials for Promoting Progenitor Cell Growth Without Serum

Overview

Journal Sci Rep

Specialty Science

Date 2013 Apr 24

PMID 23609105

Citations 1

Authors

Gaomai Yang

Libing Liu

Fengting Lv

Shu Wang

Affiliations

Soon will be listed here.

Abstract

The discovery of new active biomaterials for promoting progenitor cell growth and differentiation in serum-free medium is still proving more challenging for the clinical treatments of degenerative diseases. In this work, a conjugated polyelectrolyte, polythiophene derivative (PMNT), was discovered to significantly drive the cell cycle progression from G₁ to S and G₂ phases and thus efficiently promote the cell growth without the need of serum. Furthermore, the fluorescent characteristic of PMNT makes it simultaneously able to trace its cellular uptake and localization by cell imaging. cDNA microarray study shows that PMNT can greatly regulate genes related to cell growth or differentiation. To the best of our knowledge, this is the first example of cell growth or differentiation promotion by polyelectrolyte material without the need of serum, thereby providing an important demonstration of degenerative biomaterial discovery through polymer design.

Citing Articles

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Zhou X, Zeng Y, Tang Y, Huang Y, Lv F, Liu L Sci Adv. 2020; 6(35):eabc5237.

PMID: 32923652 PMC: 7449672. DOI: 10.1126/sciadv.abc5237.

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