Granulocyte Colony-stimulating Factor (G-CSF): a Mediator in Endometrial Receptivity for a Patient with Polycystic Ovary (PCO) Undergoing in Vitro Maturation (IVM)

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2013 Apr 23

PMID 23605819

Citations 8

Authors

Elkin Lucena

Harold Moreno-Ortiz

Affiliations

Soon will be listed here.

Abstract

Proliferative and secretory changes at the endometrial lining are the result of a complex intrauterine environment where sex steroid hormones and different local factors play an important role for endometrial thickening. Optimal endometrial thickness reflects an adequate maturation which is a key factor for embryo implantation. Here, we present a case of a woman with polycystic ovary who was treated using in vitro maturation (IVM) techniques. In addition, this patient showed a dyssynchrony between the endometrial phase characterised by endometrial thinning and the embryo development which had a negative impact for embryo implantation. A protocol using uterine perfusion of granulocyte colony-stimulating factor (G-CSF) was performed as an alternative treatment for the unresponsive endometrium. We found that uterine infusion of G-CSF quickly increased endometrial thickness resulting in a successful pregnancy and healthy born baby. These results suggest that G-CSF is a factor that participates during endometrial remodelling enhancing the synchronisation between uterine environment and embryo development.

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