Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2013 Apr 23

PMID 23601689

Citations 192

Authors

Gerlinde Obermoser

Scott Presnell

Kelly Domico

Hui Xu

Yuanyuan Wang

Esperanza Anguiano

LuAnn Thompson-Snipes

Rajaram Ranganathan

Brad Zeitner

Anna Bjork

David Anderson

Cate Speake

Emily Ruchaud

Jason Skinner

Laia Alsina

Mamta Sharma

Helene Dutartre

Alma Cepika

Elisabeth Israelsson

Phuong Nguyen

Quynh-Anh Nguyen

A Carson Harrod

Sandra M Zurawski

Virginia Pascual

Hideki Ueno

Gerald T Nepom

Charlie Quinn

Derek Blankenship

Karolina Palucka

Jacques Banchereau

Damien Chaussabel

Affiliations

Soon will be listed here.

Abstract

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

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