Preadolescent and Adolescent Risk Factors for Benign Breast Disease

Overview

Journal J Adolesc Health

Publisher Elsevier

Specialty Pediatrics

Date 2013 Apr 23

PMID 23601609

Citations 12

Authors

A Lindsay Frazier

Shoshana M Rosenberg

Affiliations

Soon will be listed here.

Abstract

Purpose: It is well established that exposures during childhood and adolescence affect breast cancer risk much later in life. Recently, studies have begun to evaluate whether early life exposures might also impact the risk of developing benign breast disease (BBD). A diagnosis of proliferative BBD independent of other breast cancer risk factors also increases the subsequent risk of breast cancer; therefore, understanding how to decrease the incidence of BBD may have important implications for primary breast cancer prevention.

Methods: We reviewed several studies from prospective cohort studies that have investigated the relationship between risk factors during childhood and adolescence, such as anthropometric and reproductive characteristics as well as diet and other behaviors, and subsequent risk of BBD.

Results: Higher intake of vegetable oils, nuts, vitamin E, and fiber and lower consumption of animal fat, red meat, and alcohol are associated with reduced risk of BBD. Childhood weight and adolescent body mass index are inversely associated with BBD risk, whereas a greater peak height velocity during adolescence is associated with a higher risk of BBD. There was no association between age of menarche and risk of BBD.

Conclusion: Early life exposures and behaviors appear to impact BBD risk. The current body of evidence further supports the importance of a life-course approach to breast cancer prevention.

Citing Articles

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Christopoulos P, Matsas A, Eleftheriades M, Kotsira G, Eleftheriades A, Vlahos N Children (Basel). 2023; 10(3).

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Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Benign Breast Diseases in a Case-Control Study.

Aghababayan S, Sheikhi Mobarakeh Z, Qorbani M, Tiznobeyk Z, Aminianfar A, Sotoudeh G J Inflamm Res. 2020; 13:61-69.

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Li J, Humphreys K, Ho P, Eriksson M, Darai-Ramqvist E, Lindstrom L JNCI Cancer Spectr. 2019; 2(3):pky051.

PMID: 31360866 PMC: 6650060. DOI: 10.1093/jncics/pky051.

References

Garland M, Hunter D, Colditz G, Spiegelman D, Manson J, Stampfer M . Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiol Biomarkers Prev. 1999; 8(11):1017-21. View

Baer H, Tworoger S, Hankinson S, Willett W . Body fatness at young ages and risk of breast cancer throughout life. Am J Epidemiol. 2010; 171(11):1183-94. PMC: 2915489. DOI: 10.1093/aje/kwq045. View

Ursin G, Longnecker M, Haile R, Greenland S . A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology. 1995; 6(2):137-41. DOI: 10.1097/00001648-199503000-00009. View

Baer H, Schnitt S, Connolly J, Byrne C, Willett W, Rosner B . Early life factors and incidence of proliferative benign breast disease. Cancer Epidemiol Biomarkers Prev. 2005; 14(12):2889-97. DOI: 10.1158/1055-9965.EPI-05-0525. View

Okasha M, McCarron P, Gunnell D, Davey Smith G . Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat. 2003; 78(2):223-76. DOI: 10.1023/a:1022988918755. View

Berkey C, Willett W, Frazier A, Rosner B, Tamimi R, Colditz G . Prospective study of growth and development in older girls and risk of benign breast disease in young women. Cancer. 2011; 117(8):1612-20. PMC: 3817000. DOI: 10.1002/cncr.25692. View

Friedenreich C, Bryant H, Alexander F, Hugh J, Danyluk J, Page D . Risk factors for benign proliferative breast disease. Int J Epidemiol. 2000; 29(4):637-44. DOI: 10.1093/ije/29.4.637. View

Tamimi R, Rosner B, Colditz G . Evaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesion. Cancer. 2010; 116(21):4944-53. PMC: 2962878. DOI: 10.1002/cncr.25386. View

Dupont W, Page D . Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med. 1985; 312(3):146-51. DOI: 10.1056/NEJM198501173120303. View

10.

Le Marchand L, Kolonel L, Earle M, MI M . Body size at different periods of life and breast cancer risk. Am J Epidemiol. 1988; 128(1):137-52. DOI: 10.1093/oxfordjournals.aje.a114936. View

11.

Russo J, Russo I . Toward a physiological approach to breast cancer prevention. Cancer Epidemiol Biomarkers Prev. 1994; 3(4):353-64. View

12.

Baer H, Schnitt S, Connolly J, Byrne C, Cho E, Willett W . Adolescent diet and incidence of proliferative benign breast disease. Cancer Epidemiol Biomarkers Prev. 2003; 12(11 Pt 1):1159-67. View

13.

Baer H, Colditz G, Rosner B, Michels K, Rich-Edwards J, Hunter D . Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res. 2005; 7(3):R314-25. PMC: 1143575. DOI: 10.1186/bcr998. View

14.

Cui Y, Page D, Lane D, Rohan T . Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast: a cohort study. Breast Cancer Res Treat. 2008; 114(1):113-20. DOI: 10.1007/s10549-008-9973-9. View

15.

Colditz G, Frazier A . Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev. 1995; 4(5):567-71. View

16.

Collins L, Baer H, Tamimi R, Connolly J, Colditz G, Schnitt S . Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health Study. Cancer. 2006; 109(2):180-7. DOI: 10.1002/cncr.22408. View

17.

Rohan T, Negassa A, Chlebowski R, Ceria-Ulep C, Cochrane B, Lane D . A randomized controlled trial of calcium plus vitamin D supplementation and risk of benign proliferative breast disease. Breast Cancer Res Treat. 2008; 116(2):339-50. PMC: 3893102. DOI: 10.1007/s10549-008-0213-0. View

18.

Longnecker M, Newcomb P, Mittendorf R, Greenberg E, Clapp R, Bogdan G . Risk of breast cancer in relation to lifetime alcohol consumption. J Natl Cancer Inst. 1995; 87(12):923-9. DOI: 10.1093/jnci/87.12.923. View

19.

Santen R, Mansel R . Benign breast disorders. N Engl J Med. 2005; 353(3):275-85. DOI: 10.1056/NEJMra035692. View

20.

Berstad P, Ma H, Bernstein L, Ursin G . Alcohol intake and breast cancer risk among young women. Breast Cancer Res Treat. 2007; 108(1):113-20. DOI: 10.1007/s10549-007-9578-8. View