Expression of the PXR Gene in Various Types of Cancer and Drug Resistance

Overview

Journal Oncol Lett

Specialty Oncology

Date 2013 Apr 20

PMID 23599746

Citations 37

Authors

Enqi Qiao

Minghua Ji

Jianzhong Wu

Rong Ma

Xiaohua Zhang

Yuejun He

Quanbin Zha

Xue Song

Li-Wei Zhu

Jinhai Tang

Affiliations

Soon will be listed here.

Abstract

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR-positive tumors.

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