Transcranial Direct-current Stimulation Increases Extracellular Dopamine Levels in the Rat Striatum

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2013 Apr 19

PMID 23596399

Citations 44

Authors

Tomoko Tanaka

Yuji Takano

Satoshi Tanaka

Naoyuki Hironaka

Kazuto Kobayashi

Takashi Hanakawa

Katsumi Watanabe

Manabu Honda

Affiliations

Soon will be listed here.

Abstract

Background: Transcranial direct-current stimulation (tDCS) is a non-invasive procedure that achieves polarity-dependent modulation of neuronal membrane potentials. It has recently been used as a functional intervention technique for the treatment of psychiatric and neurological diseases; however, its neuronal mechanisms have not been fully investigated in vivo.

Objective/hypothesis: To investigate whether the application of cathodal or anodal tDCS affects extracellular dopamine and serotonin levels in the rat striatum.

Methods: Stimulation and in vivo microdialysis were carried out under urethane anesthesia, and microdialysis probes were slowly inserted into the striatum. After the collection of baseline fractions in the rat striatum, cathodal or anodal tDCS was applied continuously for 10 min with a current intensity of 800 μA from an electrode placed on the skin of the scalp. Dialysis samples were collected every 10 min until at least 400 min after the onset of stimulation.

Results: Following the application of cathodal, but not anodal, tDCS for 10 min, extracellular dopamine levels increased for more than 400 min in the striatum. There were no significant changes in extracellular serotonin levels.

Conclusion: These findings suggest that tDCS has a direct and/or indirect effect on the dopaminergic system in the rat basal ganglia.

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