MTHFR, MTR and MTRR Polymorphisms and Risk of Chronic Kidney Disease in Japanese: Cross-sectional Data from the J-MICC Study

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2013 Apr 19

PMID 23595572

Citations 5

Authors

Asahi Hishida

Rieko Okada

Yin Guang

Mariko Naito

Kenji Wakai

Satoyo Hosono

Kazuyo Nakamura

Tanvir Chowdhury Turin

Sadao Suzuki

Hideshi Niimura

Haruo Mikami

Jun Otonari

Nagato Kuriyama

Sakurako Katsuura

Michiaki Kubo

Hideo Tanaka

Nobuyuki Hamajima

Affiliations

Soon will be listed here.

Abstract

Purpose: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data.

Methods: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype.

Results: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (≥7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate.

Conclusions: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

Citing Articles

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.

Chang H, Chen G, Hsiao P, Chiu C, Tai M, Kao C Medicine (Baltimore). 2020; 99(29):e21045.

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Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.

Corredor Z, da Silva Filho M, Rodriguez-Ribera L, Velazquez A, Hernandez A, Catalano C Sci Rep. 2020; 10(1):144.

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Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.

Chang Y, Hsu S, Tsai S, Chang Y, Huang C, Liu M Hum Brain Mapp. 2017; 38(6):3039-3051.

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Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.

Colapinto C, OConnor D, Sampson M, Williams B, Tremblay M J Public Health (Oxf). 2015; 38(2):e84-97.

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Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.

Hishida A, Wakai K, Naito M, Suma S, Sasakabe T, Hamajima N Lipids Health Dis. 2014; 13:162.

PMID: 25311932 PMC: 4210508. DOI: 10.1186/1476-511X-13-162.

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