Differentiation of Central Lung Cancer from Atelectasis: Comparison of Diffusion-weighted MRI with PET/CT

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Apr 18

PMID 23593186

Citations 16

Authors

Rui-Meng Yang

Long Li

Xin-Hua Wei

Yong-Mei Guo

Yun-Hai Huang

Li-Sha Lai

A-Mei Chen

Guo-Shun Liu

Wei-Feng Xiong

Liang-Ping Luo

Xin-Qing Jiang

Affiliations

Soon will be listed here.

Abstract

Objective: Prospectively assess the performance of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiation of central lung cancer from atelectasis.

Materials And Methods: 38 consecutive lung cancer patients (26 males, 12 females; age range: 28-71 years; mean age: 49 years) who were referred for thoracic MR imaging examinations were enrolled. MR examinations were performed using a 1.5-T clinical scanner and scanning sequences of T1WI, T2WI, and DWI. Cancers and atelectasis were measured by mapping of the apparent diffusion coefficients (ADCs) obtained with a b-value of 500 s/mm(2).

Results: PET/CT and DW-MR allowed differentiation of tumor and atelectasis in all 38 cases, but T2WI did not allow differentiation in 9 cases. Comparison of conventional T2WI and DW-MRI indicated a higher contrast noise ratio of the central lung carcinoma than the atelectasis by DW-MRI. ADC maps indicated significantly lower mean ADC in the central lung carcinoma than in the atelectasis (1.83±0.58 vs. 2.90±0.26 mm(2)/s, p<0.0001). ADC values of small cell lung carcinoma were significantly greater than those from squamous cell carcinoma and adenocarcinoma (p<0.0001 for both).

Conclusions: DW-MR imaging provides valuable information not obtained by conventional MR and may be useful for differentiation of central lung carcinoma from atelectasis. Future developments may allow DW-MR imaging to be used as an alternative to PET-CT in imaging of patients with lung cancer.

Citing Articles

The Value of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Central Lung Cancer with Obstructive Atelectasis.

Safai Zadeh E, Huber K, Gorg C, Prosch H, Findeisen H Diagnostics (Basel). 2024; 14(10).

PMID: 38786349 PMC: 11119496. DOI: 10.3390/diagnostics14101051.

Measurements of target volumes and organs at risk using DW‑MRI in patients with central lung cancer accompanied with atelectasis.

Zhang X, Liu T, Zhang H, Zhang M Mol Clin Oncol. 2023; 18(6):45.

PMID: 37152713 PMC: 10155240. DOI: 10.3892/mco.2023.2641.

Reduction of inter-observer variability using MRI and CT fusion in delineating of primary tumor for radiotherapy in lung cancer with atelectasis.

Zhang H, Fu C, Fan M, Lu L, Chen Y, Liu C Front Oncol. 2022; 12:841771.

PMID: 35992838 PMC: 9381816. DOI: 10.3389/fonc.2022.841771.

Differentiating Central Lung Tumors from Atelectasis with Contrast-Enhanced CT-Based Radiomics Features.

Chai R, Wang Q, Qin P, Zeng J, Ren J, Zhang R Biomed Res Int. 2021; 2021:5522452.

PMID: 34820455 PMC: 8608546. DOI: 10.1155/2021/5522452.

Geometric and Dosimetric Changes in Tumor and Lung Tissue During Radiotherapy for Lung Cancer With Atelectasis.

Chen H, Shao Y, Gu X, Zheng Z, Wang H, Gu H Front Oncol. 2021; 11:690278.

PMID: 34367970 PMC: 8339992. DOI: 10.3389/fonc.2021.690278.

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