Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2013 Apr 18

PMID 23592863

Citations 10

Authors

Standwell C Nkhoma

Kasia Stepniewska

Shalini Nair

Aung Pyae Phyo

Rose McGready

Francois Nosten

Tim J C Anderson

Affiliations

Soon will be listed here.

Abstract

Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols.

Citing Articles

Discrete Survival Model Analysis of Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon.

Nji A, Ali I, Niba P, Marie-Solange E, Heumann C, Froeschl G Pathogens. 2021; 10(9).

PMID: 34578139 PMC: 8465257. DOI: 10.3390/pathogens10091106.

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments-a WWARN individual patient data meta-analysis.

BMC Med. 2019; 17(1):1.

PMID: 30651111 PMC: 6335805. DOI: 10.1186/s12916-018-1207-3.

Split dosing of artemisinins does not improve antimalarial therapeutic efficacy.

White N, Watson J, Ashley E Sci Rep. 2017; 7(1):12132.

PMID: 28935919 PMC: 5608907. DOI: 10.1038/s41598-017-12483-4.

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance.

Cerqueira G, Cheeseman I, Schaffner S, Nair S, McDew-White M, Phyo A Genome Biol. 2017; 18(1):78.

PMID: 28454557 PMC: 5410087. DOI: 10.1186/s13059-017-1204-4.

Malaria parasite clearance.

White N Malar J. 2017; 16(1):88.

PMID: 28231817 PMC: 5324257. DOI: 10.1186/s12936-017-1731-1.

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