Mobility of Acetylcholine Receptors in Command Helix Lucorum Neurons in a Cellular Analog of Habituation

Overview

Journal Invert Neurosci

Date 2013 Apr 18

PMID 23591591

Citations 1

Authors

Arkady S Pivovarov

Galina B Murzina

Denis A Makhnovsky

Mariya S Tretyakova

Natalya A Vasilyeva

Affiliations

Soon will be listed here.

Abstract

We investigated the role of the mobility of acetylcholine receptors in the depression of an acetylcholine-induced inward current (ACh-current) of Helix lucorum (a land snail) command neurons of defensive behavior in a cellular analog of habituation. The inhibitors of endocytosis and exocytosis, actin microfilaments and cytoskeleton microtubules, serine/threonine protein kinases (PKA, PKG, calcium calmodulin-dependent PK II, p38 mitogen-activated PK), tyrosine kinases (including Src-family kinases), serine/threonine phosphatases (PP1, PP2A, PP2B, PPM1D), and tyrosine protein phosphatases altered the depression of the ACh-current. A comparison of experimentally calculated curves of the ACh-current of these neurons and those obtained by mathematical modeling revealed the following: (a) ACh-current depression is caused by the reduction in the number of membranous ACh-receptors, which results from the shift in the balance of multidirectional transport processes of receptors toward the predominance of ACh-receptor internalization over their recycling; (b) depression of ACh-current depends on the activity of serine/threonine and tyrosine protein kinases and protein phosphatases, whose one of the main targets is the neuron transport system-actin microfilaments and microtubules of cytoskeleton, as well as motor proteins.

Citing Articles

Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.

Bogodvid T, Andrianov V, Deryabina I, Muranova L, Silantyeva D, Vinarskaya A Front Cell Neurosci. 2018; 11:403.

PMID: 29311833 PMC: 5735116. DOI: 10.3389/fncel.2017.00403.

Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins.

Vasilyeva N, Murzina G, Pivovarov A Cell Mol Neurobiol. 2015; 35(5):703-12.

PMID: 25687906 PMC: 11486294. DOI: 10.1007/s10571-015-0165-y.

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