α-Synuclein: the Long Distance Runner

Overview

Journal Brain Pathol

Date 2013 Apr 17

PMID 23587141

Citations 45

Authors

Sonia George

Nolwen L Rey

Nicole Reichenbach

Jennifer A Steiner

Patrik Brundin

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.

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