Adipogenic Effects of Piperlonguminine in 3T3-L1 Cells and Plasma Concentrations of Several Amide Constituents from Piper Chaba Extracts After Treatment of Mice

Overview

Journal J Nat Med

Publisher Springer

Date 2013 Apr 16

PMID 23584920

Citations 3

Authors

Itadaki Yamaguchi

Hisashi Matsuda

Hailong Zhang

Makoto Hamao

Chihiro Yamashita

Yuichiro Kogami

Haruka KonI

Megumi Murata

Seikou Nakamura

Masayuki Yoshikawa

Affiliations

Soon will be listed here.

Abstract

In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased mRNA levels of adiponectin, glucose transporter 4, and fatty acid-binding protein (aP2). It also increased mRNA levels of PPARγ2 but, unlike troglitazone, piperlonguminine did not activate PPARγ directly in a nuclear receptor cofactor assay. Analyses of plasma from mice treated with piperlonguminine, piperine, and retrofractamide A, and an extract of the fruit, showed that concentrations of piperlonguminine were higher than those of piperine and retrofractamide A, and that the "area-under-the-curve" of piperine increased following in vivo administration of the extract.

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